fa P66: A Biologically Active Motif of Laminin for Spinal Cord Regeneration تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <p align="center">لطفاً به چکیده انگلیسی مراجعه شود. </p> The majority of spinal cord injuries (SCIs) are happen during road traffic accidents. Injury at any level of the spinal cord will impair respiratory function, through the destruction of motor nuclei and descending motor tracts innervating diaphragmatic, thoracic, intercostal and abdominal accessory muscles. Consequently, the majority of patients die from respiratory complications. Reconstruction and regeneration of the central nervous system following injury is a formidable task. Nerve tissue engineering (NTE) is a promising strategy that has been used to treat neural injury. The biomaterials as a substrate on which cell populations can attach and migrate, play an important role in NTE. These materials can be implanted with a combination of neural progenitor cells as a cell delivery vehicle, and be utilized as a drug carrier to deliver growth factors. Self-assembly nanopeptids can be used in the fabrication of novel biomaterials which are assembled molecule by molecule to produce novel supramolecular architectures. Recently, some of the most promising new synthetic biomaterial scaffolds are composed of self-assembling peptides that can be modified to contain laminin motifs, such as Arg-Gly-Asp-Ser (RGDS), Tyr-Ile-Gly-Ser-Arg (YIGSR) and Ile-Lys-Val-Ala-Val (IKVAV). This Hypothesis suggests that YIGSR is an efficient and safe conduit matrix for nerve regeneration after SCIs. Spinal Cord Injury, Tissue Engineering, Biomaterial Scaffold 116 116 http://shefayekhatam.ir/browse.php?a_code=A-10-24-464&slc_lang=fa&sid=1 Shahin Mohammad Sadeghi Shahin Mohammad Sadeghi drshmsadeghi@gmail.com 10031947532846005934 10031947532846005934 Yes a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Plastic Surgery Group, Medical Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran. a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Plastic Surgery Group, Medical Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Zabihollah Khaksar Zabihollah Khaksar 10031947532846005935 10031947532846005935 No Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran. Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran. Hadi Kazemi Hadi Kazemi 10031947532846005936 10031947532846005936 No a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Pediatric Department, Shahed University, Tehran, Iran. a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Pediatric Department, Shahed University, Tehran, Iran. Hadi Aligholi Hadi Aligholi 10031947532846005937 10031947532846005937 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Arezou Eshaghabadi Arezou Eshaghabadi 10031947532846005938 10031947532846005938 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Mostafa Modarres Mousavi Mostafa Modarres Mousavi 10031947532846005939 10031947532846005939 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Sajad Sahab Negah Sajad Sahab Negah 10031947532846005940 10031947532846005940 No a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran. a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran.