fa P76: The Neuroprotective Roles of NMDA Receptors Antagonist Against with Lesion in Central Nucleus of Amygdala تحقیقات پایه در علوم اعصاب Basic research in Neuroscience پژوهشي Research --- Open Access, CC-BY-NC <p align="center">لطفاً به چکیده انگلیسی مراجعه شود. </p> The N-Methyl-D-aspartic acid (NMDA) receptor is one of the specific types of ionotropic receptors which lied to glutaminergic system. It has been widely accepted that NMDA receptor neurons promote anxiety, in humans as well as in animal models. However, in the previous study seems inhibiting of this receptors decreased the protective role in neural cell. Demonstration of NMDA receptor activity had neurodegeneration effect. The hypothesis of this study based on evaluated neuroprotectivity effect of NMDA receptor inhibition in the central nucleus of the amygdala (CeA) which have role in anxiety. In this study, we confirm that NMDA antagonist (MK801) is neuroprotective when CeA had confronted regional electrical lesion. Kindling of amygdala by electrical lesion which presented by stimulation of the CeA area after microinjection of MK801 (0.5 and 0.75 µg/kg) in the kindling area is may indicate neuroprotection from secondary injury. It seems the rats were confronted electrical lesion indicated specific decreases in the percentage of open arm time and percentage of open arm entries in elevated plus maze. However, in histopathological study, the mean of dark neurons of CeA in the MK801 group was less than lesion group. We concluded that inhibited of NMDA receptors in CeA neurons may contribute to induced neuroprotection by electrical lesion. NMDA receptor, Neurodegenerative, Dark Neuron 126 126 http://shefayekhatam.ir/browse.php?a_code=A-10-24-474&slc_lang=fa&sid=1 Milad Ahmadi Milad Ahmadi pmiladz@gmail.com 10031947532846005962 10031947532846005962 Yes a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Faculty of Veterinary Medicine, Islamic Azad University, Karaj Branch, Karaj, Iran. a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Faculty of Veterinary Medicine, Islamic Azad University, Karaj Branch, Karaj, Iran. Azadeh Sajadian Azadeh Sajadian 10031947532846005963 10031947532846005963 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Hadi Aligholi Hadi Aligholi 10031947532846005964 10031947532846005964 No a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Department of Neurosciences, School of Advanced Technologies in medicine, Tehran University of Medical Sciences, Tehran, Iran. a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Department of Neurosciences, School of Advanced Technologies in medicine, Tehran University of Medical Sciences, Tehran, Iran. Babak Khodaie Babak Khodaie 10031947532846005965 10031947532846005965 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Ahmad Ali Lotfinia Ahmad Ali Lotfinia 10031947532846005966 10031947532846005966 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Mahmoud Lotfinia Mahmoud Lotfinia 10031947532846005967 10031947532846005967 No a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Shahid Beheshti University of Medical Sciences, Tehran, Iran. a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Shahid Beheshti University of Medical Sciences, Tehran, Iran.