The Neuroscience Journal of Shefaye Khatam
مجله علوم اعصاب شفای خاتم
Shefaye Khatam
Medical Sciences
http://shefayekhatam.ir
1
admin
2322-1887
2345-4814
10.61186/shefa
fa
jalali
1393
9
1
gregorian
2014
12
1
2
4
online
1
fulltext
fa
P86: Effect of Concomitant Use of Erythropoietin and Progesterone in Traumatic Brain Injury
P86: Effect of Concomitant Use of Erythropoietin and Progesterone in Traumatic Brain Injury
نوروفارماکولوژی
Neuropharmacology
پژوهشي
Research --- Open Access, CC-BY-NC
<p align="center">لطفاً به چکیده انگلیسی مراجعه شود. </p>
Traumatic brain injuries may cause some neurological deficits, such as altered level of consciousness or coma, sensory-motor dysfunction, and seizure attacks. The neuroprotective effect of progesterone and erythropoietin has been shown in different types of brain injuries and cerebral ischemia. This study aims to evaluate the probable additional neuroprotective effects of progesterone and erythropoietin after brain injury. The effects of progesterone, erythropoietin or the combination of these substances were investigated in 54 male Wistar rats suffering from traumatic brain injury. The effects of drugs were investigated using modified neurological severity scores as well as counting the number of dark neurons (injured cells) in the hippocampal CA1 and CA3 areas. Our data revealed that the scale of neurological deficits increased by co-application of progesterone and erythropoietin in brain-injured rats. Assessment of dark neurons did not show a significant decrease in the number of dark neurons after combined treatment compared to control groups. Our study showed that the combination therapy did not exhibit any synergistic effect and may worsen the outcome of traumatic brain injury. Details of this study were published (Nourzad, et al. 2014).
Neuroprotective, Motor Dysfunction, Traumatic Brain Injuries
136
136
http://shefayekhatam.ir/browse.php?a_code=A-10-24-485&slc_lang=fa&sid=1
Zahra
Nourzad
Zahra
Nourzad
10031947532846006206
10031947532846006206
No
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Tahereh
Ghadiri
Tahereh
Ghadiri
10031947532846006207
10031947532846006207
No
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Mostafa
Modarres Mousavi
Mostafa
Modarres Mousavi
10031947532846006208
10031947532846006208
No
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Fariba
Karimzadeh
Fariba
Karimzadeh
10031947532846006209
10031947532846006209
No
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Arezou
Eshaghabadi
Arezou
Eshaghabadi
10031947532846006210
10031947532846006210
No
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Hassan
Hosseini Ravandi
Hassan
Hosseini Ravandi
10031947532846006211
10031947532846006211
No
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Ali
Gorji
Ali
Gorji
gorjial@uni-muenster.de
10031947532846006212
10031947532846006212
Yes
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.