fa P86: Effect of Concomitant Use of Erythropoietin and Progesterone in Traumatic Brain Injury نوروفارماکولوژی Neuropharmacology پژوهشي Research --- Open Access, CC-BY-NC <p align="center">لطفاً به چکیده انگلیسی مراجعه شود. </p> Traumatic brain injuries may cause some neurological deficits, such as altered level of consciousness or coma, sensory-motor dysfunction, and seizure attacks. The neuroprotective effect of progesterone and erythropoietin has been shown in different types of brain injuries and cerebral ischemia. This study aims to evaluate the probable additional neuroprotective effects of progesterone and erythropoietin after brain injury. The effects of progesterone, erythropoietin or the combination of these substances were investigated in 54 male Wistar rats suffering from traumatic brain injury. The effects of drugs were investigated using modified neurological severity scores as well as counting the number of dark neurons (injured cells) in the hippocampal CA1 and CA3 areas. Our data revealed that the scale of neurological deficits increased by co-application of progesterone and erythropoietin in brain-injured rats. Assessment of dark neurons did not show a significant decrease in the number of dark neurons after combined treatment compared to control groups. Our study showed that the combination therapy did not exhibit any synergistic effect and may worsen the outcome of traumatic brain injury. Details of this study were published (Nourzad, et al. 2014). Neuroprotective, Motor Dysfunction, Traumatic Brain Injuries 136 136 http://shefayekhatam.ir/browse.php?a_code=A-10-24-485&slc_lang=fa&sid=1 Zahra Nourzad Zahra Nourzad 10031947532846006206 10031947532846006206 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Tahereh Ghadiri Tahereh Ghadiri 10031947532846006207 10031947532846006207 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Mostafa Modarres Mousavi Mostafa Modarres Mousavi 10031947532846006208 10031947532846006208 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Fariba Karimzadeh Fariba Karimzadeh 10031947532846006209 10031947532846006209 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Arezou Eshaghabadi Arezou Eshaghabadi 10031947532846006210 10031947532846006210 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Hassan Hosseini Ravandi Hassan Hosseini Ravandi 10031947532846006211 10031947532846006211 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Ali Gorji Ali Gorji gorjial@uni-muenster.de 10031947532846006212 10031947532846006212 Yes Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.