en P13: Potassium Channels and Long-Term Potentiation Formation تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <p style="text-align: center;">لطفاً به چکیده انگلیسی مراجعه شود.</p> <p style="text-align: justify;">Long-term potentiation (LTP) is a form of activity-dependent plasticity that occurs during learning. Potassium channels are the most diverse group of all ion channels that related to synaptic plasticity. Small-conductance calcium-activated potassium channels (SKs) are found in hippocampal CA1 neurons and by inhibiting of postsynaptic potentials are involved in synaptic transmission impairment. Studies have been shown that blockage of SKs result in increase of LTP so that blocking of these channels increased LTP process and vice versa. Large-conductance calcium-activated potassium channels (BKs) also are found in hippocampal CA1 neurons and by influencing synaptic plasticity play an important role in learning and memory.<br> &nbsp;</p> Potassium Channels, Synaptic Plasticity, Long-Term Potentiation 31 31 http://shefayekhatam.ir/browse.php?a_code=A-10-24-599&slc_lang=en&sid=1 Ali Jahanbazi Jahan-Abad Ali Jahanbazi Jahan-Abad a.jahanbazi65@yahoo.com 10031947532846007495 10031947532846007495 Yes Shefa Neuroscience Research Center, Khatam Alanbia Hospital Tehran, Iran Shefa Neuroscience Research Center, Khatam Alanbia Hospital Tehran, Iran Sedigheh Ghasemi Sedigheh Ghasemi 10031947532846007496 10031947532846007496 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital Tehran, Iran Shefa Neuroscience Research Center, Khatam Alanbia Hospital Tehran, Iran