en P24: The Role of Ionotropic Glutamate Receptors in the Induction of LTP تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <p style="text-align: center;">لطفاً به چکیده انگلیسی مراجعه شود.</p> <p style="text-align: justify;">Long-term potentiation (LTP) is a reflection of synaptic plasticity that has an important role in learning and memory. LTP is a long-lasting increase of synaptic activity due to enhancement of excitatory synaptic transmission after a high-frequency train of electrical stimulation. The role of &alpha;-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in excitatory synaptic transmission and LTP formation uncovered over recent decades. The activity regulation of AMPA receptors (AMPARs) has a significant role in the LTP induction. AMPARs are homomeric or heteromeric receptors combined of four subunits GLUA1 to GLUA4. GluR1 have a critical role in LTP formation in the CA1 region of hippocampus and is necessitated for synaptic delivery of AMPA receptors.</p> Long-Term Potentiation, Learning and Memory, AMPA Receptors 42 42 http://shefayekhatam.ir/browse.php?a_code=A-10-24-610&slc_lang=en&sid=1 Ali Jahanbazi Jahan-Abad Ali Jahanbazi Jahan-Abad a.jahanbazi65@yahoo.com 10031947532846007518 10031947532846007518 Yes Shefa Neuroscience Research Center, Khatam Alanbia Hospital Tehran, Iran Shefa Neuroscience Research Center, Khatam Alanbia Hospital Tehran, Iran Hassan Hosseini Ravandi Hassan Hosseini Ravandi 10031947532846007519 10031947532846007519 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital Tehran, Iran Shefa Neuroscience Research Center, Khatam Alanbia Hospital Tehran, Iran