fa P10: Reactive Glial Cells for Brain Injury تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <p style="text-align: center;">لطفاً به چکیده انگلیسی مراجعه شود.</p> <p style="text-align: justify;">A common pathological process that occurred after brain injury is gliosis. Gliosis involves the activation of glial cells to proliferate and become hypertrophic to occupy the injured brain areas. In order to form a defense system against the invasion of micro-organisms and cytotoxins into surrounding tissue, glial cells including astrocytes and microglia undergo reactive response to injury. Neuroinhibitory factors were secreted by reactive glial cells, this mechanism leads to prevent neuronal growth, eventually forming glial scar inside the brain. It have been reported that reactive glial cells showed after stroke, spinal cord injury, glioma, and neurodegenerative disorders such as Alzheimer&rsquo;s disease. Induced pluripotent stem cells is a reprogramming adult cells into pluripotent stem cells has emerged a new promise for potential stem cell therapy. Many studies showed that mouse or human fibroblasts can be differentiated into neurons or oligodendroglial cells. It has also been demonstrated that astroglial cells can be transdifferentiated into neurons or reprogrammed into neuroblast cells. It has been reported that after brain injury, reactive glial cells including astrocyte cells can be reprogrammed into functional neurons in the adult mouse cortex. Regard to this background, direct reprogramming of reactive glial cells into functional neurons In vivo could provide an alternative approach for repair of injured brain.</p> Brain Injury, Gliosis, Astroglial Cells 37 37 http://shefayekhatam.ir/browse.php?a_code=A-10-24-643&slc_lang=fa&sid=1 Sajad Sahab Negah Sajad Sahab Negah 10031947532846007748 10031947532846007748 No a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran b. Histology and Embryology Group, Basic Science Department, Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran b. Histology and Embryology Group, Basic Science Department, Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran Zabihollah Khaksar Zabihollah Khaksar 10031947532846007749 10031947532846007749 No Histology and Embryology Group, Basic Science Department, Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran Histology and Embryology Group, Basic Science Department, Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran Elham Mohammad Zadeh Elham Mohammad Zadeh 10031947532846007750 10031947532846007750 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Mostafa Modarres Mousavi Mostafa Modarres Mousavi 10031947532846007751 10031947532846007751 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Ali Jahanbazi Jahan-Abad Ali Jahanbazi Jahan-Abad 10031947532846007752 10031947532846007752 Yes Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran