fa P12: Progesterone Act as Neuroprotective in Traumatic Brain Injury تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <p style="text-align: center;">لطفاً به چکیده انگلیسی مراجعه شود.</p> <p style="text-align: justify;">Traumatic brain injury (TBI) is one of the leading causes of death in men under the age of 35 that mostly occurs due to the road accidents. Current clinical treatments have not enough repair and prevention of secondary damage caused by cytotoxicity. Progesterone, as a primary sex hormone, acts as neuroprotection in TBI and stroke. Progesterone increases anti-oxidants and decreases inflammation factors. Furthermore it contributes in axonal remyelination, and increases synaptogenesis after TBI. This review article focused on the effect of progesterone mechanisms on inflammation factor which involved in TBI. Although, many of TBI mechanisms have not been discovered, but studies showed that this hormone can be a safe treatment for TBI and other neurodegenerative diseases.</p> TBI, Progesterone, Neuroprotective 39 39 http://shefayekhatam.ir/browse.php?a_code=A-10-24-645&slc_lang=fa&sid=1 Elham Mohammadzadeh Elham Mohammadzadeh elhammohammadzadeh85@gmail.com 10031947532846007754 10031947532846007754 Yes a. Shefa Neuroscience Research, Khatam Alanbia Hospital, Tehran, Iran b. Department of Biology and Anatomical Sciences, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran a. Shefa Neuroscience Research, Khatam Alanbia Hospital, Tehran, Iran b. Department of Biology and Anatomical Sciences, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Sajad Sahab Negah Sajad Sahab Negah 10031947532846007755 10031947532846007755 No a. Shefa Neuroscience Research, Khatam Alanbia Hospital, Tehran, Iran b. Histology and Embryology group, Basic Science Department, Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran a. Shefa Neuroscience Research, Khatam Alanbia Hospital, Tehran, Iran b. Histology and Embryology group, Basic Science Department, Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran Arezou Eshaghabadi Arezou Eshaghabadi 10031947532846007756 10031947532846007756 No Shefa Neuroscience Research, Khatam Alanbia Hospital, Tehran, Iran Shefa Neuroscience Research, Khatam Alanbia Hospital, Tehran, Iran