fa ?P21: Is Interleukin-1 Beta Correlated with Intra Cranial Pressure after Traumatic Brain Injury تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <p style="text-align: center;">لطفاً به چکیده انگلیسی مراجعه شود.</p> <p style="text-align: justify;">Traumatic brain injury is a leading cause of disability and death from injury in the world. The Interleukin-1 (IL-1) is a family of cytokines that act as key mediators of the inflammatory response peripherally and centrally. Based on many studies, researchers found that the IL-1 is the well-known molecule in relation to acute TBI in the models of both focal and diffuse injuries. The IL-1 family includes the closely related agonists IL-1&alpha; and IL-1&beta;. Interleukin-1 beta (IL-1&beta;) is a pro-inflammatory cytokine with a key role in the inflammatory response following TBI and studies indicate that attenuation of this cytokine improves behavioral outcomes. IL-1&beta; is measurable in the serum or CSF of healthy individuals. Although changes in IL-1&beta; expression in CSF and serum following injury appear to be small, attempts have been made to correlate IL-1&beta; levels with outcome. It have been reported that in severe brain injury patients, high concentrations of IL-1&beta; in CSF were associated with poor outcome and increased intra cranial pressure.</p> TBI, IL-1β, Intra Cranial Pressure 48 48 http://shefayekhatam.ir/browse.php?a_code=A-10-24-654&slc_lang=fa&sid=1 Sajad Sahab Negah Sajad Sahab Negah 10031947532846007775 10031947532846007775 No a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran b. Histology and Embryology Group, Department of Basic Sciences, Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran b. Histology and Embryology Group, Department of Basic Sciences, Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran Zabihollah Khaksar Zabihollah Khaksar 10031947532846007776 10031947532846007776 No Histology and Embryology Group, Department of Basic Sciences, Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran Histology and Embryology Group, Department of Basic Sciences, Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran Ali Jahanbazi Jahan-Abad Ali Jahanbazi Jahan-Abad a.jahanbazi65@yahoo.com 10031947532846007777 10031947532846007777 Yes Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Arezou Eshaghabadi Arezou Eshaghabadi 10031947532846007778 10031947532846007778 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Mostafa Modarres Mousavi Mostafa Modarres Mousavi 10031947532846007779 10031947532846007779 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Hassan Hossini Ravandi Hassan Hossini Ravandi 10031947532846007780 10031947532846007780 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran