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Immune System in Central Nervous System
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Samira Ghorbani Gazar *   , Farideh Talebi |
| Tehran University of Medical Sciences, Tehran, Iran , Sghourbani@yahoo.com |
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Abstract: (12696 Views) |
| Introduction:
Although central nervous system (CNS) has long been known as an immune privileged site,
in common with all other tissues, it requires effective immune mechanisms to protect against infections.
More recent data support that certain areas of healthy CNS are continuously monitored by resident
microglia and blood-borne immune cells such as macrophage and T-cell to sustain CNS immune surveillance.
Interruption of CNS surveillance by lymphocyte traffic inhibition results in injury and infection by
viruses such as JC virus, herpes simplex virus, etc. CNS Immune system has to be regulated in a unique
way in order to prevent inflammation and autoimmune reactions against CNS derived antigens, which
there is no tolerance for them.
Conclusion:
Here, we discuss the anatomical and cellular aspects of immune
surveillance in the CNS. Moreover, we review a new model to explain how antigen-specific T-cell
responses occur in the CNS. |
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| Keywords: Autoimmune Diseases, Neurogenic Inflammation, Multiple Sclerosis |
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Full-Text [PDF 1884 kb]
(2655 Downloads)
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Type of Study: Review --- Open Access, CC-BY-NC |
Subject:
Basic research in Neuroscience
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