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:: Volume 11, Issue 3 (Summer 2023) ::
Shefaye Khatam 2023, 11(3): 110-126 Back to browse issues page
Drug Nanocarriers as a Potential Therapeutic Strategy in Glioblastoma Multiforme
Sohrab Heydarian *
Department of Veterinary, Agriculture Faculty, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran. , drsohrab.hey@gmail.com
Abstract:   (1333 Views)
Introduction: Glioblastoma multiforme (GBM) is one of the most common tumors with high mortality and a very aggressive nature. Blood-brain barrier (BBB) limits the penetration of chemotherapy drugs into the tumor tissue. Recent studies have shown that the use of various drug nanocarriers to treat GBM can provide new and effective strategies. These nanocarriers have been successful in targeted drug delivery and mainly include carbon nanotubes, metal nanoparticles, nanoemulsions, microcapsules, polymeric micelles, dendrimers, niosomes, liposomes, and pyrosomes. The ability to accurately and directly deliver drugs to GBM cells via nanocarriers has been able to increase the effectiveness and reduce the side effects of chemotherapy drugs. Conclusion: In this review article, the use of different types of drug nanocarriers is reviewed in the treatment of glioblastoma multiforme, and the future therapeutic perspectives of this method are discussed to overcome the limitations of GBM therapy.
Keywords: Glioblastoma, Blood-Brain Barrier, Nanotechnology
Full-Text [PDF 1645 kb]   (698 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Neuropharmacology
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Heydarian S. Drug Nanocarriers as a Potential Therapeutic Strategy in Glioblastoma Multiforme. Shefaye Khatam 2023; 11 (3) :110-126
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مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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