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دوره 9 شماره 1 صفحات 200-209 برگشت به فهرست نسخه ها
اثر ضد تشنجی رژیم غذایی کتوژنیک در درمان صرع
فائزه یعقوبی، مریم جعفریان، علی گرجی*
الف. مرکز تحقیقات علوم اعصاب شفا، بیمارستان خاتم الانبیاء، تهران، ایران. ب. مرکزتحقیقات صرع، دانشگاه مونستر، مونستر، آلمان ، gorjial@uni-muenster.de
چکیده:   (1021 مشاهده)
مقدمه: صرع نوعی اختلال مزمن مغزی می‌باشد که حدود 1 درصد از جمعیت کل جهان مبتلا به آن هستند. از این میان حدود یک سوم افراد مبتلا به صرع مقاوم به دارو هستند که توسط داروهای ضد تشنج بهبود نمی‌یابند. رژیم کتوژنیک یک رژیم غذایی با چربی بالا، کربوهیدرات پایین و پروتئین محدود می‌باشد. رژیم کتوژنیک یک تغییر اساسی در متابولیسم بدن ایجاد می‌نماید به گونه‌ایی که بدن و مغز برای سوخت و ساز از اجسام کتونی به‌عنوان جایگزین گلوکز استفاده می‌نمایند. اساساً این رژیم در برخی بیماران مقاوم به داروهای ضدتشنج کمک کننده می ‏باشد. نتیجه‌گیری: حفظ و نگه داشتن این رژیم در طولانی مدت تاثیرات مثبتی داشته و در کودکان نسبت به بزرگسالان نتیجه بخش‌تر است اما سبب ایجاد عوارض جانبی هم چون سنگ‌کلیه، شکستگی استخوان و کلسترول بالا می‌شود. در این مطالعه، مروری بر ارتباط رژیم کتوژنیک و اختلال صرع صورت گرفته است و مکانیسم‏ های بالقوۀ عملکرد آن مورد بحث قرار گرفته است.
واژه‌های کلیدی: رژیم کتوژنیک، متابولیسم، صرع
متن کامل [PDF 712 kb]   (477 دریافت)    
نوع مطالعه: مروری | موضوع مقاله: تحقیقات پایه در علوم اعصاب
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yaghoubi F, Jafarian M, Gorji A. The Anticonvulsant Effect of the Ketogenic Diet in the Treatment of Epilepsy. Shefaye Khatam. 2020; 9 (1) :200-209
URL: http://shefayekhatam.ir/article-1-2065-fa.html

یعقوبی فائزه، جعفریان مریم، گرجی علی. اثر ضد تشنجی رژیم غذایی کتوژنیک در درمان صرع. مجله علوم اعصاب شفای خاتم. 1399; 9 (1) :200-209

URL: http://shefayekhatam.ir/article-1-2065-fa.html



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دوره 9، شماره 1 - ( زمستان 1399 ) برگشت به فهرست نسخه ها
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