[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit ::
Main Menu
Home::
Journal Information::
About the Journal & Policies
Editorial Board
Articles Archive::
Current Issue
All Issues
Guide for Authors::
Author instructions
Guide for publishing in journal
Submission Form
Author's consent form
For Reviewers::
Reviewers Section
Ethical Statements::
Registration::
Registration Form
Site Facilities::
Site map
Inform to friends
Contact us::
Contact Information
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Copyright Policies

 

AWT IMAGE

 
..
Open Access Policy

This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

..
:: Volume 10, Issue 2 (Spring 2022) ::
Shefaye Khatam 2022, 10(2): 104-110 Back to browse issues page
New Drugs and their Mechanism in the Treatment of Epilepsy
Tahereh Karimi shayan , Asadollah Asadi , Arash Abdolmaleki *
Department of Bioinformatics, Faculty of Advanced Technologies, University of Mohaghegh Ardabili, Namin, Iran , Abdolmalekiarash1364@gmail.com
Abstract:   (1244 Views)
Introduction: Epilepsy is a neurological disorder in which neuronal hyperexcitability causes seizures. This neurological disorder occurs in the hippocampus or cerebral cortex, and the neuronal network excitability affect the CA1 region of the hippocampus more than any other areas. Accordingly, studies have been conducted on the use of new methods of prescribing drugs to treat this disease. Novel methods increase effectiveness and reduce toxicity compared to oral antiepileptic drugs. The purpose of these new methods is to bring the optimal concentration of the drug to the epileptogenic zone. Conclusion: People with epilepsy need long-term drug treatment. Therefore, it is important to identify safe, tolerable, and effective drugs.
Keywords: Epilepsy, Seizures, Methods
Full-Text [PDF 952 kb]   (1373 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Neurophysiology
References
1. Anwar H, Khan QU, Nadeem N, Pervaiz I, Ali M, Cheema FF. Epileptic seizures. Discoveries. 2020; 8(2). [DOI:10.15190/d.2020.7]
2. Pfisterer U, Petukhov V, Demharter S, Meichsner J, Thompson JJ, Batiuk MY, et al. Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis. Nature communications. 2020; 11(1): 1-19. [DOI:10.1038/s41467-020-18752-7]
3. Yaghoubi F, Jafarian M, Gorji A. The Anticonvulsant Effect of the Ketogenic Diet in the Treatment of Epilepsy. The Neuroscience Journal of Shefaye Khatam. 2020, 9(1): 200-09. [DOI:10.52547/shefa.9.1.200]
4. Russ SA, Larson K, Halfon N. A national profile of childhood epilepsy and seizure disorder. Pediatrics. 2012; 129(2): 256-64. [DOI:10.1542/peds.2010-1371]
5. Lagae L. The need for broad spectrum and safe anti-epileptic drugs in childhood epilepsy. Acta Neurol Belg. 2009; 109(3): 167-70.
6. Kobayashi K, Endoh F, Ohmori I, Akiyama T. Action of antiepileptic drugs on neurons. Brain and Development. 2020; 42(1): 2-5. [DOI:10.1016/j.braindev.2019.07.006]
7. Abumurad S, Issa NP, Wu S, Rose S, Esengul YT, Nordli D, et al. Laser interstitial thermal therapy for NPRL3-related epilepsy with multiple seizure foci: A case report. Epilepsy & Behavior Reports. 2021: 100459. [DOI:10.1016/j.ebr.2021.100459]
8. Rogawski MA, Löscher W, Rho JM. Mechanisms of action of antiseizure drugs and the ketogenic diet. Cold Spring Harbor perspectives in medicine. 2016; 6(5): a022780. [DOI:10.1101/cshperspect.a022780]
9. Abdolmaleki A, Moghimi A, Ghayour MB, Rassouli MB. Evaluation of neuroprotective, anticonvulsant, sedative and anxiolytic activity of citicoline in rats. European journal of pharmacology. 2016; 789: 275-9. [DOI:10.1016/j.ejphar.2016.07.048]
10. Soluki M, Mahmoudi F, Abdolmaleki A, Asadi A, Sabahi Namini A. Cerium oxide nanoparticles as a new neuroprotective agent to promote functional recovery in a rat model of sciatic nerve crush injury. British Journal of Neurosurgery. 2020: 1-6. [DOI:10.1080/02688697.2020.1864292]
11. Schipper S, Aalbers M, Rijkers K, Swijsen A, Rigo J, Hoogland G, et al. Tonic GABA A receptors as potential target for the treatment of temporal lobe epilepsy. Molecular neurobiology. 2016; 53(8): 5252-65. [DOI:10.1007/s12035-015-9423-8]
12. Rogawski MA, Tofighy A, White HS, Matagne A, Wolff C. Current understanding of the mechanism of action of the antiepileptic drug lacosamide. Epilepsy research. 2015; 110: 189-205. [DOI:10.1016/j.eplepsyres.2014.11.021]
13. Powell KL, Cain SM, Snutch TP, O'Brien TJ. Low threshold T‐type calcium channels as targets for novel epilepsy treatments. British journal of clinical pharmacology. 2014; 77(5): 729-39. [DOI:10.1111/bcp.12205]
14. Nilo A, Pauletto G, Gigli GL, Vogrig A, Dolso P, Valente M. Perampanel as add-on therapy in epilepsies with known etiology: A single center experience with long-term follow-up. Epilepsy & Behavior Reports. 2021; 15: 100393. [DOI:10.1016/j.ebr.2020.100393]
15. Cherian A, Shetty SC, Divya K, Pavuluri H. Weekly methotrexate may reduce valproate levels causing relapse of genetic generalized epilepsy. Epilepsy & Behavior Reports. 2021; 16. [DOI:10.1016/j.ebr.2021.100457]
16. Dreischmeier E, Zuloaga A, Kotloski RJ, Karasov AO, Gidal BE. Levetiracetam-associated irritability and potential role of vitamin B6 use in veterans with epilepsy. Epilepsy & Behavior Reports. 2021; 16: 100452. [DOI:10.1016/j.ebr.2021.100452]
17. Upadhaya PG, Pulakkat S, Patravale VB. Nose-to-brain delivery: exploring newer domains for glioblastoma multiforme management. Drug delivery and translational research. 2020. [DOI:10.1007/s13346-020-00747-y]
18. Pardridge WM. The blood-brain barrier: bottleneck in brain drug development. NeuroRx. 2005; 2(1): 3-14. [DOI:10.1602/neurorx.2.1.3]
19. Kwan P, Brodie MJ. Early identification of refractory epilepsy. New England Journal of Medicine. 2000; 342(5): 314-19. [DOI:10.1056/NEJM200002033420503]
20. Bennewitz MF, Saltzman WM. Nanotechnology for delivery of drugs to the brain for epilepsy. Neurotherapeutics. 2009; 6(2): 323-36. [DOI:10.1016/j.nurt.2009.01.018]
21. Sonvico F, Clementino A, Buttini F, Colombo G, Pescina S, Stanisçuaski Guterres S, et al. Surface-modified nanocarriers for nose-to-brain delivery: from bioadhesion to targeting. Pharmaceutics. 2018; 10(1): 34. [DOI:10.3390/pharmaceutics10010034]
22. Tayab ZR, Hochhaus G. Pharmacokinetic/pharmacodynamic evaluation of inhalation drugs: application to targeted pulmonary delivery systems. Expert opinion on drug delivery. 2005; 2(3): 519-32. [DOI:10.1517/17425247.2.3.519]
23. Fisher RS, Chen DK. New routes for delivery of anti-epileptic medications. Acta Neurologica Taiwanica. 2006; 15(4): 225.
24. Heiss JD, Walbridge S, Morrison P, Hampton RR, Sato S, Vortmeyer A, et al. Local distribution and toxicity of prolonged hippocampal infusion of muscimol. Journal of neurosurgery. 2005; 103(6): 1035-45. [DOI:10.3171/jns.2005.103.6.1035]
25. Stein AG, Eder HG, Blum DE, Drachev A, Fisher RS. An automated drug delivery system for focal epilepsy. Epilepsy research. 2000; 39(2): 103-14. [DOI:10.1016/S0920-1211(99)00107-2]
26. Anschel DJ, Ortega E, Fisher RS. Diazepam prophylaxis for bicuculline-induced seizures: a rat dose-response model. Neuroscience letters. 2004; 356(1): 66-8. [DOI:10.1016/j.neulet.2003.10.082]
27. Litt B, Echauz J. Prediction of epileptic seizures. The Lancet Neurology. 2002; 1(1): 22-30. [DOI:10.1016/S1474-4422(02)00003-0]
28. Dowd E, Monville C, Torres EM, Wong LF, Azzouz M, Mazarakis ND, et al. Lentivector‐mediated delivery of GDNF protects complex motor functions relevant to human Parkinsonism in a rat lesion model. European Journal of Neuroscience. 2005; 22(10): 2587-95. [DOI:10.1111/j.1460-9568.2005.04414.x]

XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
karimi shayan T, Asadi A, Abdolmaleki A. New Drugs and their Mechanism in the Treatment of Epilepsy. Shefaye Khatam 2022; 10 (2) :104-110
URL: http://shefayekhatam.ir/article-1-2236-en.html
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 10, Issue 2 (Spring 2022) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
Persian site map - English site map - Created in 0.07 seconds with 44 queries by YEKTAWEB 4645