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:: Volume 5 - The Spring Supplement of Shefaye Khatam 2 - ::
Shefaye Khatam 2017, 5 - The Spring Supplement of Shefaye Khatam 2 -: 11-11 Back to browse issues page
O 11: Diagnosis and Management of Neuromyelitis Optica
Mohammad Ali Sahraian *
Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran , sahraian1350@yahoo.com
Abstract:   (3842 Views)

Typical NMO is characterized by simultaneous or sequential acute transverse myelitis and optic neuritis. Spinal cord lesions extending over 3 or more vertebral segments and normal brain imaging are the typical MRI findings in NMO. In typical cases with positive NMO antibody the diagnosis is easy but in seronegative and atypical cases with different clinical manifestations and MRI features the diagnosis will be challenging. Brain stem syndromes such as ataxia, intractable vomiting and cranial nerve palsies are less common initial manifestations of NMO.  Shorter spinal cord lesions in MRI can be found very early during relapse or in residual atrophic stages. Some of the lesions may appear hypointense on corresponding T1-weighted images which reflects sever inflammation with necrosis. T1-weighted hypointensities may help in differentiating NMO lesions from MS in spinal cord. Brain MRI is initially normal in most patients with NMO but serial imaging may depict lesions in up to 85% of the patients at later stages. Brain lesions are usually nonspecific but may fulfill the Barkhof criteria for dissemination in space. Acute, large, edematous callosal lesions with a heterogeneous intensity occasionally develop in patients with NMO (marbled pattern). In contrast, in MS, callosal lesions are small, non-edematous, and the intensity was homogeneous in the acute phase and located at the lower margin of the corpus callosum. Multiple patchy enhancements with blurred margins (cloudlike enhancement) have been reported to be typical for NMO. Pencil-like ependymal enhancement is another type of enhancement around the anterior horns of lateral ventricles. Extensive hemispheric lesions, periependymal lesions surrounding the aqueduct, the third and fourth ventricles and brain stem lesions should raise the diagnosis of NMO. Actually NMO should be considered in any atypical lesion for MS in appropriate clinical settings. Other auto anti bodies such as anti MOG  have extended the spectrum of this entity and should be evaluated in special cases who are seronegative for anti-aquaporin 4. Treatment of NMO consists of acute relapse management with steroids and/or plasma exchange and prevention of exacerbations with cytoxic agents or Rituximab. 

Keywords: Neuromyelitis Optica, Inflammation, Spinal cord
Full-Text [PDF 208 kb]   (782 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


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Sahraian M A. O 11: Diagnosis and Management of Neuromyelitis Optica. Shefaye Khatam 2017; 5 (S2) :11-11
URL: http://shefayekhatam.ir/article-1-1165-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 5 - The Spring Supplement of Shefaye Khatam 2 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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