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:: Volume 5 - The Spring Supplement of Shefaye Khatam 2 - ::
Shefaye Khatam 2017, 5 - The Spring Supplement of Shefaye Khatam 2 -: 59-59 Back to browse issues page
P 28: Bone Marrow-Derived Mesenchymal Stem Cells Reduces Neuroinflammation and Splenic Cytolytic CD8 + T Cells in Mice with Experimental Autoimmune Encephalomyelitis
Amir Ghaemi * , Leila Alizadeh , Gelareh Vakilzadeh , Soodeh Razeghi Jahromi
a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran b. Department of Virology, Institute Pasteur of Iran, Tehran, Iran , ghaem_amir@yahoo.com
Abstract:   (3820 Views)

Introduction: Multiple sclerosis (MS) has been recognized as a common neurodegenerative disease that occurs after an Auto reactive T cells against myelin antigens.  Demyelination and inflammation are the main features of this disease. The anti-inflammatory and neuroprotective roles of bone marrow-derived mesenchymal stem cells (BM-MSCs) have been considered as a suitable treatment against autoimmune diseases. Previous studies have shown that treatment with BM-MSCs may regulate immune responses and improve the symptoms in experimental autoimmune encephalomyelitis (EAE) mice, an animal model of multiple sclerosis. Therefore, the present study was designed to evaluate immunomodulatory effects of BM-MSCs in the treatment of myelin oligodendrocyte glycoprotein (MOG) 35-55-induced EAE in C57BL/6 mice. Materials and Methods: MSCs were obtained from the bone marrow of C57BL mice, cultured with DMEM/F12, and characterized with flow cytometer for the presence of cell-surface markers for BM-MSCs. Following three passages, BM-MSCs were injected intraperitoneally into EAE mice. Immunological responses of the transplantation were evaluated. Results: The results demonstrated that BM-MSCs transplantation in EAE mice significantly reduced inflammation infiltration and demyelination, enhanced the immunomodulatory functions, and inhibited progress of neurological impairments compared to control groups. Conclusion: This study suggests the potential of BM-MSCs to induce immunomodulatory and anti-inflammatory roles in the treatment of neuroinflammatory disorders.

Keywords: Multiple sclerosis, Stem cells, Neuroinflammation, Cytokine, Neuroprotection
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Type of Study: Research --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


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Ghaemi A, Alizadeh L, Vakilzadeh G, Razeghi Jahromi S. P 28: Bone Marrow-Derived Mesenchymal Stem Cells Reduces Neuroinflammation and Splenic Cytolytic CD8 + T Cells in Mice with Experimental Autoimmune Encephalomyelitis. Shefaye Khatam 2017; 5 (S2) :59-59
URL: http://shefayekhatam.ir/article-1-1213-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 5 - The Spring Supplement of Shefaye Khatam 2 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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