[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit ::
Main Menu
Home::
Journal Information::
Articles Archive::
Guide for Authors::
For Reviewers::
Ethical Statements::
Registration::
Site Facilities::
Contact us::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Copyright Policies

 

AWT IMAGE

 

..
Open Access Policy

This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

..
:: Volume 5, Issue 2 (Spring - 2017) ::
Shefaye Khatam 2017, 5(2): 88-97 Back to browse issues page
Seladin-1: A Possible Neuroprotective Agent in Alzheimer's Disease
Sedigheh Ghasemi , Sara Abdolahi , Hoda Pasand Mojdeh , Maryam Borhani-Haghighi *
a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran , borhanihm@gmail.com
Abstract:   (6449 Views)

Introduction: Alzheimer's disease is a progressive brain dysfunction, which damages and destroys neurons and results in memory loss. Selective Alzheimer's disease indicator-1 (seladin-1) is a gene and protein that is found to be down-regulated in specific areas of the brain affected by Alzheimer's disease. Seladin-1 has neuroprotective properties and inhibits caspase-3 activity, a key mediator of apoptosis. Seladin-1 is a multi-functional protein and independently of its activity as a caspase-3 inhibitor, it acts as a cholesterol biosynthetic enzyme. Cholesterol enhances the formation of lipid rafts inhibits the production of β-amyloid in the membrane of neural cell. Cholesterol homeostasis disorder in neural cells may enhance susceptibility of cells to the toxic agents. Conclusion: Studies have shown that the level of seladin-1 increases during brain development to prevent the loss of neuronal precursor cells. Estrogen and thyroid hormones stimulate the expression of seladin-1. It seems that seladin-1 may act as a mediator of these hormones.

Keywords: Alzheimer Disease, Neuroprotective Agents, Cholesterol
Full-Text [PDF 857 kb]   (2538 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Neurology



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ghasemi S, Abdolahi S, Pasand Mojdeh H, Borhani-Haghighi M. Seladin-1: A Possible Neuroprotective Agent in Alzheimer's Disease. Shefaye Khatam 2017; 5 (2) :88-97
URL: http://shefayekhatam.ir/article-1-1368-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 5, Issue 2 (Spring - 2017) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
Persian site map - English site map - Created in 0.06 seconds with 45 queries by YEKTAWEB 4645