Seladin-1: A Possible Neuroprotective Agent in Alzheimer's Disease
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Sedigheh Ghasemi , Sara Abdolahi , Hoda Pasand Mojdeh , Maryam Borhani-Haghighi * |
a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran , borhanihm@gmail.com |
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Abstract: (6449 Views) |
Introduction: Alzheimer's disease is a progressive brain dysfunction, which damages and destroys neurons and results in memory loss. Selective Alzheimer's disease indicator-1 (seladin-1) is a gene and protein that is found to be down-regulated in specific areas of the brain affected by Alzheimer's disease. Seladin-1 has neuroprotective properties and inhibits caspase-3 activity, a key mediator of apoptosis. Seladin-1 is a multi-functional protein and independently of its activity as a caspase-3 inhibitor, it acts as a cholesterol biosynthetic enzyme. Cholesterol enhances the formation of lipid rafts inhibits the production of β-amyloid in the membrane of neural cell. Cholesterol homeostasis disorder in neural cells may enhance susceptibility of cells to the toxic agents. Conclusion: Studies have shown that the level of seladin-1 increases during brain development to prevent the loss of neuronal precursor cells. Estrogen and thyroid hormones stimulate the expression of seladin-1. It seems that seladin-1 may act as a mediator of these hormones. |
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Keywords: Alzheimer Disease, Neuroprotective Agents, Cholesterol |
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Full-Text [PDF 857 kb]
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Type of Study: Review --- Open Access, CC-BY-NC |
Subject:
Neurology
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