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P11: The Role of Aquaporin-4Receotors in Mesial Temporal Epilepsy
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Zeinab Najmi   , Mostafa Modarres Mousavi * |
| a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran , modarres.mousavi@gmail.com |
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Abstract: (2804 Views) |
| Introduction: Aquaporin-4 (AQP4) express in glial cells and plays a crucial role in brain water and ion homeostasis during rapid neural activity. Only AQP-4 has been found in astrocyte, which is widely expressed throughout the brain, especially in the cerebrospinal fluid and cerebrospinal fluid (CSF) interface, which may have contributed to edema and CSF absorption. Mesial temporal lobe epilepsy (MTLE) is a chronic seizure disorder that is often refractory to epilepsy treatment. The main cause of MTLE is not fully understood, but the ability to hyperexcitability in neuronal networks is an essential feature. Loss of AQP4 from perivascular endfeet of sclerotic hippocampus contributes to increased seizure propensity in human MTLE. Conclusion: In conclusion, mislocalization of AQP4 in different regions of hippocampus may contribute to the epileptogenicity of the MTLE patients. |
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| Keywords: Temporal Epilepsy, Glial Cells, AQP4, Epileptogenicity |
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Full-Text [PDF 260 kb]
(604 Downloads)
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Type of Study: Review --- Open Access, CC-BY-NC |
Subject:
Basic research in Neuroscience
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