Stress-Induced Immune Dysfunction: Implications for Intrapersonal and Interpersonal Processes

Sepehrinezhad, Ali; Momeni, Javad; Gorji, Ali; Sahab Negah, Sajad

doi:10.29252/shefa.8.2.93

[Home ] [Archive]

[ فارسی ]

The Neuroscience Journal of Shefaye Khatam

Main Menu

Home

Journal Information

Articles Archive

Guide for Authors

For Reviewers

Ethical Statements

Registration

Site Facilities

Contact us

Search in website

Receive site information

Open Access Policy

This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge.

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

Volume 8, Issue 2 (Spring 2020)

Shefaye Khatam 2020, 8(2): 93-106

Back to browse issues page

Stress-Induced Immune Dysfunction: Implications for Intrapersonal and Interpersonal Processes

Ali Sepehrinezhad

, Javad Momeni

, Ali Gorji

, Sajad Sahab Negah ^*

a. Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. b. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran , sahabnegahs@mums.ac.ir

Abstract: (5232 Views)

Introduction: Psychoneuroimmunology researchers have focused on experimental and clinical investigations to figure out how stressors and their negative emotions can affect the physiological alterations and impact on health. Clinical investigations show that the central nervous system interacts with the endocrine and immune systems in a bidirectional manner. Stress-induced immune dysregulation is occurred by the humoral and cellular immune responses. Furthermore, chronic stress can promote the production of proinflammatory cytokines, such as interleukin (IL)-6, which leads to an increase of a variety of chronic diseases. Conclusion: Given the impact of stress on health outcomes, it is necessary to improve our knowledge on the implicated pathways in which stress affects immune functioning, as well as the psychological factors that may impair or improve the effects of stress on immune responses. The aim of this study was to review the recent investigations on the role of stress on immune system and the psychological factors that may regulate this effect.

Keywords: Immune System, Psychoneuroimmunology, Health

Full-Text [PDF 682 kb] (15347 Downloads)

Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience

References

1. Kemeny ME, Schedlowski M. Understanding the interaction between psychosocial stress and immune-related diseases: a stepwise progression. Brain Behav Immun. 2007; 21(8): 1009-18. [DOI:10.1016/j.bbi.2007.07.010]

2. Urbinati EC, Zanuzzo FS, Biller JD. Stress and immune system in fish. Baldisserotto B, Urbinati EC, Cyrino JEP. Biology and Physiology of Freshwater Neotropical Fish: Academic Press; 2020. p. 93-114. [DOI:10.1016/B978-0-12-815872-2.00005-1]

3. Goldstein DS, McEwen B. Allostasis, homeostats, and the nature of stress. Stress. 2002; 5(1): 55-8. [DOI:10.1080/102538902900012345]

4. Cohen S, Janicki-Deverts D, Miller GE. Psychological stress and disease. Jama. 2007; 298(14): 1685-7. [DOI:10.1001/jama.298.14.1685]

5. Dhabhar FS. Effects of stress on immune function: the good, the bad, and the beautiful. Immunol Res. 2014; 58(2-3): 193-210. [DOI:10.1007/s12026-014-8517-0]

6. Koyama S, Ishii KJ, Coban C, Akira S. Innate immune response to viral infection. Cytokine. 2008; 43(3): 336-41. [DOI:10.1016/j.cyto.2008.07.009]

7. Oberholzer A, Oberholzer C, Moldawer LL. Sepsis syndromes: understanding the role of innate and acquired immunity. Shock. 2001; 16(2): 83-96. [DOI:10.1097/00024382-200116020-00001]

8. Medzhitov R. Recognition of microorganisms and activation of the immune response. Nature. 2007; 449(7164): 819-26. [DOI:10.1038/nature06246]

9. Raison CL, Capuron L, Miller AH. Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol. 2006; 27(1): 24-31. [DOI:10.1016/j.it.2005.11.006]

10. Elenkov IJ. Neurohormonal-cytokine interactions: implications for inflammation, common human diseases and well-being. Neurochem Int. 2008; 52(1-2): 40-51. [DOI:10.1016/j.neuint.2007.06.037]

11. Chaudhry A, Samstein RM, Treuting P, Liang Y, Pils MC, Heinrich JM, et al. Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation. Immunity. 2011; 34(4): 566-78. [DOI:10.1016/j.immuni.2011.03.018]

12. Hering D, Lachowska K, Schlaich M. Role of the sympathetic nervous system in stress-mediated cardiovascular disease. Curr Hypertens Rep. 2015; 17(10): 80. doi: 10.1007/s11906-015-0594-5. [DOI:10.1007/s11906-015-0594-5]

13. Steptoe A, Hamer M, Chida Y. The effects of acute psychological stress on circulating inflammatory factors in humans: a review and meta-analysis. Brain Behav Immun. 2007; 21(7): 901-12. [DOI:10.1016/j.bbi.2007.03.011]

14. Enman NM, Sabban EL, McGonigle P, Van Bockstaele EJ. Targeting the neuropeptide Y system in stress-related psychiatric disorders. Neurobiol Stress. 2015; 1: 33-43. [DOI:10.1016/j.ynstr.2014.09.007]

15. Beurel E, Nemeroff CB. Interaction of stress, corticotropin-releasing factor, arginine vasopressin and behaviour. Curr Top Behav Neurosci. 2014; 18: 67-80. [DOI:10.1007/7854_2014_306]

16. Curtis GC, Abelson JL, Gold PW. Adrenocorticotropic hormone and cortisol responses to corticotropin-releasing hormone: changes in panic disorder and effects of alprazolam treatment. Biol Psychiatry. 1997; 41(1): 76-85. [DOI:10.1016/S0006-3223(95)00578-1]

17. Kalliokoski O, Jellestad FK, Murison R. A systematic review of studies utilizing hair glucocorticoids as a measure of stress suggests the marker is more appropriate for quantifying short-term stressors. Sci Rep. 2019; 9(1): 11997. doi: 10.1038/s41598-019-48517-2. [DOI:10.1038/s41598-019-48517-2]

18. De Bosscher K, Vanden Berghe W, Haegeman G. The interplay between the glucocorticoid receptor and nuclear factor-κb or activator protein-1: molecular mechanisms for gene repression. Endocr Rev. 2003; 24(4): 488-522. [DOI:10.1210/er.2002-0006]

19. Nance DM, Sanders VM. Autonomic innervation and regulation of the immune system (1987-2007). Brain Behav Immun. 2007; 21(6): 736-45. [DOI:10.1016/j.bbi.2007.03.008]

20. Scanzano A, Cosentino M. Adrenergic regulation of innate immunity: a review. Front Pharmacol. 2015; 6: 171. doi: 10.3389/fphar.2015.00171. [DOI:10.3389/fphar.2015.00171]

21. Glaser R, Kiecolt-Glaser JK. Stress-induced immune dysfunction: implications for health. Nat Rev Immunol. 2005; 5(3): 243-51. [DOI:10.1038/nri1571]

22. Tracey KJ. Reflex control of immunity. Nat Rev Immunol. 2009; 9(6): 418-28. [DOI:10.1038/nri2566]

23. Tracey KJ. The inflammatory reflex. Nature. 2002; 420(6917): 853-9. [DOI:10.1038/nature01321]

24. Borovikova LV, Ivanova S, Zhang M, Yang H, Botchkina GI, Watkins LR, et al. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature. 2000; 405(6785): 458-62. [DOI:10.1038/35013070]

25. Bilbo SD, Dhabhar FS, Viswanathan K, Saul A, Yellon SM, Nelson RJ. Short day lengths augment stress-induced leukocyte trafficking and stress-induced enhancement of skin immune function. Proc Natl Acad Sci U S A. 2002; 99(6): 4067-72. [DOI:10.1073/pnas.062001899]

26. Dhabhar FS, Miller AH, McEwen BS, Spencer RL. Stress-induced changes in blood leukocyte distribution. Role of adrenal steroid hormones. J Immunol. 1996; 157(4): 1638-44.

27. Morrow-Tesch JL, McGlone JJ, Norman RL. Consequences of restraint stress on natural killer cell activity, behavior, and hormone levels in rhesus macaques (Macaca mulatta). Psychoneuroendocrinology. 1993; 18(5-6): 383-95. [DOI:10.1016/0306-4530(93)90013-B]

28. Redwine L, Mills PJ, Sada M, Dimsdale J, Patterson T, Grant I. Differential immune cell chemotaxis responses to acute psychological stress in Alzheimer caregivers compared to non-caregiver controls. Psychosom Med. 2004; 66(5): 770-5. [DOI:10.1097/01.psy.0000138118.62018.87]

29. Dhabhar FS, Viswanathan K. Short-term stress experienced at time of immunization induces a long-lasting increase in immunologic memory. Am J Physiol Regul Integr Comp Physiol. 2005; 289(3): R738-44. [DOI:10.1152/ajpregu.00145.2005]

30. Wood PG, Karol MH, Kusnecov AW, Rabin BS. Enhancement of antigen-specific humoral and cell-mediated immunity by electric footshock stress in rats. Brain Behav Immun. 1993; 7(2): 121-34. [DOI:10.1006/brbi.1993.1014]

31. Coe CL, Lubach G, Ershler WB. Immunological consequences of maternal separation in infant primates. New Directions for Child and Adolescent Development. 1989; 1989(45): 65-91. [DOI:10.1002/cd.23219894507]

32. Dhabhar FS, McEwen BS. Stress-induced enhancement of antigen-specific cell-mediated immunity. J Immunol. 1996; 156(7): 2608-15.

33. Dhabhar FS, Saul AN, Daugherty C, Holmes TH, Bouley DM, Oberyszyn TM. Short-term stress enhances cellular immunity and increases early resistance to squamous cell carcinoma. Brain Behav Immun. 2010; 24(1): 127-37. [DOI:10.1016/j.bbi.2009.09.004]

34. Dhabhar FS, Satoskar AR, Bluethmann H, David JR, McEwen BS. Stress-induced enhancement of skin immune function: A role for gamma interferon. Proc Natl Acad Sci U S A. 2000; 97(6): 2846-51. [DOI:10.1073/pnas.050569397]

35. Altemus M, Rao B, Dhabhar FS, Ding W, Granstein RD. Stress-induced changes in skin barrier function in healthy women. J Invest Dermatol. 2001; 117(2): 309-17. [DOI:10.1046/j.1523-1747.2001.01373.x]

36. Prather AA, Puterman E, Epel ES, Dhabhar FS. Poor sleep quality potentiates stress-induced cytokine reactivity in postmenopausal women with high visceral abdominal adiposity. Brain Behav Immun. 2014; 35: 155-62. [DOI:10.1016/j.bbi.2013.09.010]

37. Dhabhar FS. Enhancing versus suppressive effects of stress on immune function: implications for immunoprotection and immunopathology. Neuroimmunomodulation. 2009; 16(5): 300-17. [DOI:10.1159/000216188]

38. Dhabhar FS, McEwen BS. Acute stress enhances while chronic stress suppresses cell-mediated immunity in vivo: a potential role for leukocyte trafficking. Brain Behav Immun. 1997; 11(4): 286-306. [DOI:10.1006/brbi.1997.0508]

39. Smith A, Vollmer-Conna U, Bennett B, Wakefield D, Hickie I, Lloyd A. The relationship between distress and the development of a primary immune response to a novel antigen. Brain Behav Immun. 2004; 18(1): 65-75. [DOI:10.1016/S0889-1591(03)00107-7]

40. Fleshner M, Laudenslager ML, Simons L, Maier SF. Reduced serum antibodies associated with social defeat in rats. Physiol Behav. 1989; 45(6): 1183-7. [DOI:10.1016/0031-9384(89)90107-8]

41. Brown DH, Zwilling BS. Activation of the hypothalamic-pituitary-adrenal axis differentially affects the anti-mycobacterial activity of macrophages from BCG-resistant and susceptible mice. J Neuroimmunol. 1994; 53(2): 181-7. [DOI:10.1016/0165-5728(94)90028-0]

42. Zoccola PM, Figueroa WS, Rabideau EM, Woody A, Benencia F. Differential effects of poststressor rumination and distraction on cortisol and C-reactive protein. Health Psychol. 2014; 33(12): 1606-9. [DOI:10.1037/hea0000019]

43. Thomsen DK, Mehlsen MY, Hokland M, Viidik A, Olesen F, Avlund K, et al. Negative thoughts and health: Associations among rumination, immunity, and health care utilization in a young and elderly sample. Psychosomatic Medicine. 2004; 66(3): 363-71. [DOI:10.1097/00006842-200405000-00012]

44. Boren JP, Veksler AE. Co-rumination and immune inflammatory response in healthy young adults: Associations with interleukin-6 and C-reactive protein. Communication Research Reports. 2018; 35(2): 152-61. [DOI:10.1080/08824096.2017.1409619]

45. Gross JJ. Antecedent-and response-focused emotion regulation: divergent consequences for experience, expression, and physiology. J Pers Soc Psychol. 1998; 74(1): 224-37. [DOI:10.1037/0022-3514.74.1.224]

46. Gross JJ, John OP. Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. J Pers Soc Psychol. 2003; 85(2): 348-62. [DOI:10.1037/0022-3514.85.2.348]

47. Appleton AA, Buka SL, Loucks EB, Gilman SE, Kubzansky LD. Divergent associations of adaptive and maladaptive emotion regulation strategies with inflammation. Health Psychol. 2013; 32(7): 748-56. [DOI:10.1037/a0030068]

48. Stanton AL, Danoff-Burg S, Cameron CL, Ellis AP. Coping through emotional approach: Problems of conceptualizaton and confounding. J Pers Soc Psychol. 1994; 66(2): 350-62. [DOI:10.1037/0022-3514.66.2.350]

49. Hoyt MA, Stanton AL, Bower JE, Thomas KS, Litwin MS, Breen EC, et al. Inflammatory biomarkers and emotional approach coping in men with prostate cancer. Brain Behav Immun. 2013; 32: 173-9. [DOI:10.1016/j.bbi.2013.04.008]

50. Master SL, Amodio DM, Stanton AL, Yee CM, Hilmert CJ, Taylor SE. Neurobiological correlates of coping through emotional approach. Brain Behav Immun. 2009; 23(1): 27-35. [DOI:10.1016/j.bbi.2008.04.007]

51. Guilbaud O, Corcos M, Hjalmarsson L, Loas G, Jeammet P. Is there a psychoneuroimmunological pathway between alexithymia and immunity? Immune and physiological correlates of alexithymia. Biomed Pharmacother. 2003; 57(7): 292-5. [DOI:10.1016/S0753-3322(03)00085-4]

52. Bruni R, Serino FM, Galluzzo S, Coppolino G, Cacciapaglia F, Vadacca M, et al. Alexithymia and neuroendocrine‐immune response in patients with autoimmune diseases: preliminary results on relationship between alexithymic construct and TNF‐α levels. Ann N Y Acad Sci. 2006; 1069(1): 208-11. [DOI:10.1196/annals.1351.018]

53. McIntosh RC, Ironson G, Antoni M, Kumar M, Fletcher MA, Schneiderman N. Alexithymia is linked to neurocognitive, psychological, neuroendocrine, and immune dysfunction in persons living with HIV. Brain Behav Immun. 2014; 36: 165-75. [DOI:10.1016/j.bbi.2013.10.024]

54. Brown GW, Harris T. Social origins of depression: A study of psychiatric disorder in women. 1st ed. Routledge. 2012; p. 416. [DOI:10.4324/9780203714911]

55. Godbout JP, Glaser R. Stress-induced immune dysregulation: implications for wound healing, infectious disease and cancer. J Neuroimmune Pharmacol. 2006; 1(4): 421-7. [DOI:10.1007/s11481-006-9036-0]

56. Robles TF, Kiecolt-Glaser JK. The physiology of marriage: Pathways to health. Physiol Behav. 2003; 79(3): 409-16. [DOI:10.1016/S0031-9384(03)00160-4]

57. Kiecolt-Glaser JK, Loving TJ, Stowell JR, Malarkey WB, Lemeshow S, Dickinson SL, et al. Hostile marital interactions, proinflammatory cytokine production, and wound healing. Arch Gen Psychiatry. 2005; 62(12): 1377-84. [DOI:10.1001/archpsyc.62.12.1377]

58. Uchino BN, Holt-Lunstad J, Uno D, Flinders JB. Heterogeneity in the social networks of young and older adults: Prediction of mental health and cardiovascular reactivity during acute stress. J Behav Med. 2001; 24(4): 361-82. [DOI:10.1023/A:1010634902498]

59. Uchino BN, Bosch JA, Smith TW, Carlisle M, Birmingham W, Bowen KS, et al. Relationships and cardiovascular risk: Perceived spousal ambivalence in specific relationship contexts and its links to inflammation. Health Psychol. 2013; 32(10): 1067-75. [DOI:10.1037/a0033515]

60. Slavich GM, O'Donovan A, Epel ES, Kemeny ME. Black sheep get the blues: A psychobiological model of social rejection and depression. Neurosci Biobehav Rev. 2010; 35(1): 39-45. [DOI:10.1016/j.neubiorev.2010.01.003]

61. Murphy ML, Slavich GM, Rohleder N, Miller GE. Targeted rejection triggers differential pro-and anti-inflammatory gene expression in adolescents as a function of social status. Clin Psychol Sci. 2013; 1(1): 30-40. [DOI:10.1177/2167702612455743]

62. Slavich GM, Irwin MR. From stress to inflammation and major depressive disorder: a social signal transduction theory of depression. Psychol Bull. 2014; 140(3): 774-815. [DOI:10.1037/a0035302]

63. Raison CL, Miller A. The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D). Mol Psychiatry. 2013; 18(1): 15-37. [DOI:10.1038/mp.2012.2]

64. Scheier MF, Carver CS. Optimism, coping, and health: assessment and implications of generalized outcome expectancies. Health Psychol. 1985; 4(3): 219-47. [DOI:10.1037/0278-6133.4.3.219]

65. Roy B, Diez-Roux AV, Seeman T, Ranjit N, Shea S, Cushman M. Association of optimism and pessimism with inflammation and hemostasis in the multi-ethnic study of atherosclerosis (MESA). Psychosom Med. 2010; 72(2): 134-40. [DOI:10.1097/PSY.0b013e3181cb981b]

66. Ikeda A, Schwartz J, Peters JL, Fang S, Spiro III A, Sparrow D, et al. Optimism in relation to inflammation and endothelial dysfunction in older men: the VA normative aging study. Psychosomatic Medicine. 2011; 73(8): 664-71. [DOI:10.1097/PSY.0b013e3182312497]

67. Kim ES, Hagan KA, Grodstein F, DeMeo DL, De Vivo I, Kubzansky LD. Optimism and cause-specific mortality: a prospective cohort study. Am J Epidemiol. 2017; 185(1): 21-9. [DOI:10.1093/aje/kww182]

68. Segerstrom SC, Castañeda JO, Spencer TE. Optimism effects on cellular immunity: testing the affective and persistence models. Personality and Individual Differences. 2003; 35(7): 1615-24. [DOI:10.1016/S0191-8869(02)00384-7]

69. Pressman SD, Black LL. Positive emotions and immunity. The Oxford handbook of psychoneuroimmunology. 2012; 92-104. [DOI:10.1093/oxfordhb/9780195394399.013.0006]

‎ 10.29252/shefa.8.2.93

Mendeley

Zotero

RefWorks

Sepehrinezhad A, Momeni J, Gorji A, Sahab Negah S. Stress-Induced Immune Dysfunction: Implications for Intrapersonal and Interpersonal Processes. Shefaye Khatam 2020; 8 (2) :93-106
URL: http://shefayekhatam.ir/article-1-2056-en.html

Rights and permissions
	This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Volume 8, Issue 2 (Spring 2020)

Back to browse issues page

Persian site map - English site map - Created in 0.05 seconds with 45 queries by YEKTAWEB 4645