:: دوره 9، شماره 3 - ( تابستان 1400 ) ::
دوره 9 شماره 3 صفحات 129-116 برگشت به فهرست نسخه ها
سلول‌های بنیادی و کاربرد آن‌ها برای درمان آسیب‌های سیستم عصبی مرکزی
مجید حسن پورعزتی* ، زهرا نیکوکار
گروه زیست شناسی، دانشکده علوم پایه، دانشگاه شاهد، تهران، ایران ، hassanpour@shahed.ac.ir
چکیده:   (2582 مشاهده)
مقدمه: تصادف، سقوط، آسیب‌های ورزشی و تروما شایع‌ترین علل آسیب‌های مغزی و نخاعی هستند که منجر به نقص در عملکردهای حسی و حرکتی می‌شوند. تلاش‌های زیادی برای استفاده از سلول‌های بنیادی برای ترمیم و جلوگیری از ایجاد عوارض ناشی از آسیب به سیستم عصبی مرکزی صورت گرفته است. چالش اصلی در این زمینه انتخاب سلول‌های بنیادی مناسب برای جایگزینی سلول‌های عصبی از دست رفته و جلوگیری از فرآیندهایی است که عملکرد سلول‌های بنیادی را مختل می‌کنند. در این مقالۀ مروری، اطلاعات فعلی در مورد سلول‌های بنیادی مختلف مورد استفاده در درمان آسیب به سیستم عصبی، مکانیسم‌های احتمالی عملکرد آن‌ها مورد بحث قرار گرفته است. علاوه بر این، مزایا و معایب درمان با سلول‌های بنیادی بر اساس یافته‌های مطالعات پایه و بالینی شرح داده شده است. هزینه بالای درمان با سلول‌های بنیادی و عوارض جانبی ناخواسته، چالش‌های اصلی در استفاده درمانی از سلول‌های بنیادی برای ترمیم سیستم عصبی هستند. بنابراین تحقیقات بیشتری برای بهینه سازی رویکردهای سلول درمانی در محیط‌های بالینی مورد نیاز است. نتیجه‌گیری: وجود انواع مختلف سلول‌های بنیادی با قابلیت‌های متنوع و رفع مشکلات موجود می‌تواند امید به استفاده از سلول‌درمانی برای درمان آسیب‌های سیستم عصبی را افزایش دهد.
واژه‌های کلیدی: آسیب‌ های طناب نخاعی، درمان مبتنی بر سلول و بافت، سلول‌های بنیادی
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نوع مطالعه: مروری | موضوع مقاله: ترميم عصبي
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دوره 9، شماره 3 - ( تابستان 1400 ) برگشت به فهرست نسخه ها