[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit ::
Main Menu
Home::
Journal Information::
Articles Archive::
Guide for Authors::
For Reviewers::
Ethical Statements::
Registration::
Site Facilities::
Contact us::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Copyright Policies

 

AWT IMAGE

 

..
Open Access Policy

This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

..
:: Volume 1, Issue 1 (Winter - 2013) ::
Shefaye Khatam 2013, 1(1): 19-23 Back to browse issues page
Application of Patient-Specific Induced Pluripotent Stem Cells Produced by Somatic Cells Reprogramming for Treatment of Neurodegenerative Diseases
Mostafa Modarres Mousavi , Amir Ghaemi , Tahere Ghadiri , Shahin Mohammad Sadeghi *
Shahid Beheshti University of Medical Sciences, Tehran, Iran. , drshmsadeghi@gmail.com
Abstract:   (15317 Views)
Introduction: Neurodegenerative diseases, depending on the cause and condition of disease, destroy neuronal and glial cells at different regions of the brain and the spinal cord. Due to unknown pathogenesis of these diseases, definite treatment is still not available. Furthermore, there is no reliable patient-specific model for experimental and clinical investigations. Despite emerging of new therapeutic methods such as embryonic and adult stem cell therapies in last decades, difficulty of maintaining embryonic stem cells for a long duration, aggressive process of adult stem cells extraction as well as difficulties to differentiation to all variety of cell lines, limited the usage of these techniques for treatment of the patients. Conclusion: Novel method of induced Pluripotent Stem (iPS) cells production by somatic cells reprogramming may be useful for the treatment of neurodegenerative diseases. The investigators succeed to produce reliable patient-specific iPS cells models for some neurodegenerative diseases such as amyotrophic lateral sclerosis and Parkinson disease.
Keywords: ips Cells, Multipotent Stem Cells, Neurodegenerative Diseases, Cell Death
Full-Text [PDF 1771 kb]   (3058 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Modarres Mousavi M, Ghaemi A, Ghadiri T, Mohammad Sadeghi S. Application of Patient-Specific Induced Pluripotent Stem Cells Produced by Somatic Cells Reprogramming for Treatment of Neurodegenerative Diseases. Shefaye Khatam 2013; 1 (1) :19-23
URL: http://shefayekhatam.ir/article-1-24-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 1, Issue 1 (Winter - 2013) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
Persian site map - English site map - Created in 0.06 seconds with 45 queries by YEKTAWEB 4645