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The Effect of Spreading Depression on Glycoconjugates of Dentate Gyrus in Rats
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Maryam Jafarian *   , Fariba Karimzadeh , Sadegh Rahimi , Seyed Mahmoud Hosseini , Elham Mohammadzadeh , Alireza Fazel |
| Deptartment of Anatomy, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. , jafaryanm@yahoo.com |
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Abstract: (12233 Views) |
| Introduction:
Spreading depression (SD) is a pathophysiological phenomenon caused by repetitive depolarization
of neurons and glial cells. There is a relationship between SD and some disorders, such as migraine
with aura. Glycoconjugates play an important role in cell proliferation and differentiation. It has
been shown that SD can stimulate the neurogenesis. In the present study, the effect of SD on expressing
and distribution of glycoconjugates was evaluated.
Materials & Methods: Forty rats (30-45 days) were divided
into two groups: 1 week and 1 month each group was contained three subgroups: control, sham
and SD. Two and four SD was induced by KCL injection in 1 week and 1 month groups, respectively. Histochemical
studies were performed by using five different horse radish peroxidase labeled lectins, including
PNA, VVA, MPA and LTA in polymorph layer of hippocampal dentate gyrus.
Results: There were no differences
in the expression of three lectins (PNA, VVA, and MPA) in all different groups. However, induction
of SD significantly enhanced the expression of LTA compared with sham and control groups.
Conclusion:
Higher intensity reaction of LTA indicates a possible role of L-focuses monosaccharide in changes of synaptic
plasticity induced by SD. |
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| Keywords: Cortical Spreading Depression, Dentate Gyrus, Lectins |
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Full-Text [PDF 1788 kb]
(2371 Downloads)
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Type of Study: Research --- Open Access, CC-BY-NC |
Subject:
Neurophysiopathology
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