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:: Volume 2, Issue 4 (Autumn - 2014) ::
Shefaye Khatam 2014, 2(4): 60-70 Back to browse issues page
Immunomodulatory Role of Mesenchymal Stem Cells against Multiple Sclerosis
Amir Ghaemi, Shahnaz Babaei Abraki, Sedigheh Ghasemi, Azadeh Sajadian, Mansoureh Togha *
Iranian Center of Neurological Research, Neuroscience Research Institute, Tehran University of Medical Sciences, Tehran, Iran. , toghae@tums.ac.ir
Abstract:   (6305 Views)

Introduction: Multiple sclerosis (MS) is an autoimmune disease of central nervous system that is characterized by the progressive loss of myelin. In addition to immunoregulatory properties, novel MS therapies promote myelin repair activities. Mesenchymal stem cells (MSCs) have been viewed as a potent tool for regenerative and immunosuppressive functions, indicating a potential therapy for MS. MSCs have immunological functions which are exerted by direct cell-to-cell contacts, secretion of stimulatory and inhibitory cytokines, and/or a combination of both mechanisms. Therefore, these cells can inhibit differentiation and proliferation of T-cell and stimulate the Th2 and regulatory T-cells through inhibitory effects on the immune system. Conclusion: In the current review, we discuss the mechanisms underlying the immunomodulatory effect of MSCs in different experimental models of MS.

Keywords: Cell- and Tissue-Based Therapy, Immunomodulation, Multiple Sclerosis, Mesenchymal Stromal Cells
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Type of Study: Review --- Open Access, CC-BY-NC | Subject: Neuroimmunology

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Ghaemi A, Babaei Abraki S, Ghasemi S, Sajadian A, Togha M. Immunomodulatory Role of Mesenchymal Stem Cells against Multiple Sclerosis. Shefaye Khatam. 2014; 2 (4) :60-70
URL: http://shefayekhatam.ir/article-1-319-en.html

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Volume 2, Issue 4 (Autumn - 2014) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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