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:: Volume 1, Issue 3 (Summer - 2013) ::
Shefaye Khatam 2013, 1(3): 38-48 Back to browse issues page
Roles of Excitatory and Inhibitory Receptors in Spreading Depression
Ahmad Ali Lotfinia , Babak Khodaie , Mahmoud Lotfinia , Milad Ahmadi , Maryam Jafarian *
School of Advance Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. , jafarian.m34@gmail.com
Abstract:   (12766 Views)

Introduction: Spreading depression (SD) is a pathophysiological phenomenon, which induced as consequence of ischemia, cerebral hemorrhage and cerebral injury. SD roles in some clinical disorders, including migraine aura, epilepsy, head injury and transient global amnesia, have been documented. SD is a neural hyperactivity, which slowly spread in the brain, passed through neurons or astrocyte, change blood volume, cell metabolism and distribute cell ionic balance. SD is accompanied by a transient hyperactivity, which continues by neuronal depression and hyperexcitability. Conclusion: Various investigation on animal and human brains showed enhancement in NMDA, AMPA, GABA as well as serotonin after SD. This review focuses on wide range of investigation on excitatory and inhibitory neurotransmitters after SD.

Keywords: Cortical Spreading Depression, Glutamates, Epilepsy, Central Nervous System
Full-Text [PDF 3502 kb]   (2966 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Neurophysiopathology



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Lotfinia A A, Khodaie B, Lotfinia M, Ahmadi M, Jafarian M. Roles of Excitatory and Inhibitory Receptors in Spreading Depression. Shefaye Khatam 2013; 1 (3) :38-48
URL: http://shefayekhatam.ir/article-1-45-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 1, Issue 3 (Summer - 2013) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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