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:: Volume 3 - The Summer Supplement of Shefaye Khatam 2 - ::
Shefaye Khatam 2015, 3 - The Summer Supplement of Shefaye Khatam 2 -: 21-21 Back to browse issues page
P3: Mechanisms of TrkB-Mediated Hippocampal Long-Term Potentiation in Learning and Memory
Ali Jahanbazi Jahan-Abad * , Hassan Hosseini Ravandi
Shefa Neuroscience Research Center, Khatam Alanbia Hospital Tehran, Iran , a.jahanbazi65@yahoo.com
Abstract:   (3622 Views)

Long-term potentiation (LTP) is a process that certain types of synaptic stimulation lead to a long-lasting enhancement in the strength of synaptic transmission. Studies in recent years indicate the importance of molecular pathways in the development of memory and learning. Tropomyosin receptor kinase B (TrkB) is a member of the neurotrophin receptor tyrosine kinase family, that its ligand is brain-derived neurotrophic factor (BDNF). In recent years, Research has been shown that TrkB has an important role in LTP formation in hippocampus and after ligand binding activates several intracellular signaling cascades. Three important intracellular signaling cascades are triggered by the TrkB receptor includes: Ras–mitogen activated protein kinase (MAPK) pathway, phosphatidylinositol 3‑kinase (PI3K)-Akt pathway and PLCγ-Ca 2+ pathway.
 

Keywords: Long-Term Potentiation, Neurotrophin Receptor Tyrosine kinase, Brain‑Derived Neurotrophic Factor
Full-Text [PDF 157 kb]   (1107 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


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Jahanbazi Jahan-Abad A, Hosseini Ravandi H. P3: Mechanisms of TrkB-Mediated Hippocampal Long-Term Potentiation in Learning and Memory. Shefaye Khatam 2015; 3 (S2) :21-21
URL: http://shefayekhatam.ir/article-1-793-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 3 - The Summer Supplement of Shefaye Khatam 2 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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