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Volume 3 - The Summer Supplement of Shefaye Khatam 2 -
Shefa Neuroscience Research Center, Khatam Alanbia Hospital Tehran, Iran , a.jahanbazi65@yahoo.com
Abstract: (3563 Views)
Long-term potentiation (LTP) is a biological process of learning and memory after a high-frequency train of electrical stimulations. By binding of brain-derived neurotrophic factor (BDNF) to Tropomyosin receptor kinase B (TrKB) receptors in postsynaptic neurons, tyrosine kinase Fyn is bound to these receptors and hereby plays a mediating role to binding and activation of N-methyl-D-aspartic acid receptors (NMDARs). TrkB receptor can be initiated three different pathway includes: MAPK pathway, PI3K-Akt pathway and PLCγ-Ca 2+ pathway. So Fyn by playing a mediating role between TrkB signaling pathway and NMDARs has an important role in LTP induction.
Jahanbazi Jahan-Abad A, Ghasemi S. P22: The Association between TrkB Signaling Pathway and NMDARs in LTP Induction. Shefaye Khatam 2015; 3 (S2) :40-40 URL: http://shefayekhatam.ir/article-1-812-en.html