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:: Volume 3 - The Summer Supplement of Shefaye Khatam 2 - ::
Shefaye Khatam 2015, 3 - The Summer Supplement of Shefaye Khatam 2 -: 40-40 Back to browse issues page
P22: The Association between TrkB Signaling Pathway and NMDARs in LTP Induction
Ali Jahanbazi Jahan-Abad * , Sedigheh Ghasemi
Shefa Neuroscience Research Center, Khatam Alanbia Hospital Tehran, Iran , a.jahanbazi65@yahoo.com
Abstract:   (3563 Views)

Long-term potentiation (LTP) is a biological process of learning and memory after a high-frequency train of electrical stimulations. By binding of brain-derived neurotrophic factor (BDNF) to Tropomyosin receptor kinase B (TrKB) receptors in postsynaptic neurons, tyrosine kinase Fyn is bound to these receptors and hereby plays a mediating role to binding and activation of N-methyl-D-aspartic acid receptors (NMDARs). TrkB receptor can be initiated three different pathway includes: MAPK pathway, PI3K-Akt  pathway and PLCγ-Ca 2+ pathway. So Fyn by playing a mediating role between TrkB signaling pathway and NMDARs has an important role in LTP induction.

Keywords: Long-Term Potentiation, Tyrosine kinase Fyn, Learning and Memory
Full-Text [PDF 169 kb]   (1285 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience


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Jahanbazi Jahan-Abad A, Ghasemi S. P22: The Association between TrkB Signaling Pathway and NMDARs in LTP Induction. Shefaye Khatam 2015; 3 (S2) :40-40
URL: http://shefayekhatam.ir/article-1-812-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 3 - The Summer Supplement of Shefaye Khatam 2 - Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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