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Showing 4 results for Mohebbi
Shahrzad Mohebbi, Mojdeh Ghabaee, Majid Ghaffarpour, Ali Pasha Meisami, Reza Shahsiah, Mohammadreza Mousavi Mirkola, Zahra Zeinali Kahki, Maryam Pourashraf, Hoda Ghadami,
Volume 1, Issue 3 (Summer - 2013)
Abstract
Introduction: Systemic inflammatory response occurs after ischemic events in stroke and is responsible for thrombosis progression. In this study, we are intended to evaluate association of C- Reactive Protein (CRP) as an inflammatory marker with acute cerebral ischemic attack variables, risk factors and mortality. Materials & Methods: 162 patients with acute ischemic stroke were enrolled in the study. Medical history was asked and physical examination was performed. Then venous blood samples were drawn from all of the patients at end of the first day. Results: Our results showed that association between high sensitive CRP (hsCRP) and early mortality in the patients with acute CVA was significant. 10% of patients were died within a week after the stroke onset. mean of CRP in died patients was 8.9±7 mg/dl and in survived patients was 2.2±5 mg/dl (p=0.0001). After multivariate analysis and adjusting variables for sex, age, history of heart disease, NIHSS Score and TOAST, we found hsCRP as an independent factor in predicting early onset mortality. Conclusion: This study shows that hsCRP has a direct association with mortality within the first week after stroke and measuring hsCRP within the first hours after stroke may play an important role in determining of patients´ mortality risk.
Malihe Hassan Nia, Hossein Mohebbi, Nafise Bahrami, Zahra Ghane,
Volume 5, Issue 2 (The Spring Supplement of Shefaye Khatam 2 - 2017)
Abstract
Zinc is a substance that regulates neural excitability by binding whit sodium channel and potassium channel. The efficiency of free zinc ion, make down the neural survival rate, reduced the peak amplitude of Na+ and make depolarization Na channel, increased the peak amplitude of transition outward k+ currents and delayed rectifier. Also it is an effective blocker of one subtype of tetrodoxine (TT-X) insensitive sodium channel than other sodium channel. Absolutely zinc effects on other proteins membrane and the suitable level of free zinc ion help to membranes function. In neuroinflammation zone, the membrane get into new environment and the protein channel hardly make impulse. In some neuroinflammation disease that neuron's problem is inability to make impulse, the efficiency of free zinc ion makes that and increase level of zinc ion, help neuron makes impulse. For example in Alzheimer, if the levels of zinc get increased, neuron make impulse and the process of disease get slowly. But neuroinflammation disease that neuron make excessive impulse and this is main problem, like Multiple Sclerosis, efficiency of free zinc ion help to decrease membrane activities. In neuroinflammation disease, when the protein membrane get into damage, use of zinc in drug in other to improve the efficiency of free zinc ion, can help to protein channel and membrane function. In the other site, increase the level of free zinc ion make excessive impulse. So free zinc ion in matrix is really important for action protein membrane and in neuroinflammation environment, changing the level make different result. If in a disease neuron action get down, zinc in drug can help to make impulse by binding whit protein channel.
Seyed Ali Seyedinia, Hossein Ali Safakhah, Tahereh Taghavi, Parnia Tarahomi, Abbas Ali Vafaei, Mina Sokhanvar, Narges Mohebbi, Ali Rashidy- Pour,
Volume 6, Issue 2 (The Spring Supplement of Shefaye Khatam 1 - 2018)
Abstract
Neuropathic pain is caused by a lesion or disease affecting the nervous systems, and is generally manifested as spontaneous pain, hyperalgesia, and allodynia. Previous study indicate that saffron has anti-inflammatory and antioxidant properties, we investigated whether saffron and crocin, a major constitute of saffron, would infleuence on behavioral responses of pain induced by chronic constriction injury (CCI). Adult male Wistar rats (200 to 250 g) were randomly assigned into 6 groups: Sham, CCI, CCI+ Saline, CCI+Saffron (30mg/kg) and CCI +Crocin (15) and CCI +Crocin (30). CCI was induced by setting four loose ligatures around the left siatic nerve of the rat. Two weeks after nerve lesion, injections of saline, saffron or crocin were started and continued every 24 hours until the day 26 post-surgery. Pain behavioral responses including mechanical allodynia (von Frey filament testing) and thermal hyperalgesia were measured at days 14, 17, 20, 23, 26, and 40 after CCI. CCI induced a long-lasting hyperalgesia to nocious heat and mechanical allodynia. Treatment with saffron and crocin (30 mg/kg) decreased thermal hyperalgesia and mechanical allodynia from the days 20-23 after surgery that lasted until the day 40. The lower dose of crocin (15 mg/kg) only decreased mechanical alodynia from the day 23 after CCI that lasted until the day 40. These findings indicate that treatment with saffron and crocin after CCI may have a therapeutic effect, suggesting that these substances may offer new strategies for the treatment of this highly debilitating condition.
Masume Dodange, Mehdi Ghanimati, Zahra Mohebbi, Maryam Puryaghoob,
Volume 6, Issue 2 (The Spring Supplement of Shefaye Khatam 1 - 2018)
Abstract
MS illness is a self- safety and inflammatory illness in Central Nervous System in which Myelin Sheath and Axon of neuronal cells of the brain and the spinal cord is destroyed by the Safety System, and the level of its prevalence is two or three times more in women rather than men. The most important complications of this illness are fatigue, cramp, shake, the lack of balance, and walking disorder. These factors cause the sharp drop of the level of quality in these patients' life, and it results in reduction of their daily activities. This study aims at investigating the effect of exercise on the rate of fatigue and the quality of life in patients with Multiple Sclerosis. The performance of sports exercises proportional to the ability of patients with MS can decreases the cost of Physiology, and therefore it can improve the rate of fatigue and the level of quality in their life if the symptoms such as thermal sensitivity and fatigue isn't exacerbate. Thus, it is recommended to do these exercises as an effective and time-consuming way, because it has the ability for learning and it is easy to perform. Regarding these results, the respective experts can use these exercises as a complementary along with medical treatments for patients with MS, and they can prevent these patients' increasing and quick disability.
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