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Inflammation is a pathologic condition that includes a wide range of diseases namely neurodegenerative diseases. Several natural anti-inflammatory components have been identified in plant extracts used in traditional medicine for the relief of inflammation. Herbal medicine is showing difficulty in crossing the blood-brain barrier (BBB). So that the ability to pass the BBB is the main concern for using them at neurodegenerative diseases treatment. Nano-Liposomes and Noisomes provide a unique opportunity to deliver pharmaceuticals into the cells and interaction with the target site. So they have been considered as Nano-carriers for brain drug targeting and overcoming the BBB and transition anti-inflammation herbal medicine namely curcumin for neurodegenerative disease curing. The aim of this review is to explore the different approaches studied to transport and deliver herbal medicine to the brain by using liposome and noisome systems as a carrier. This review has analyzed the most recent approaches for herbal medicine delivery to the central nervous system (CNS). The overall literature clearly shows that herbal medicine needs a modern delivery system for treatment of neurodegenerative disease. Several systems have been used to deliver drugs to the brain, such as using peptides, antibodies, and RNA aptamers for optimizing targeting ability liposomes and noisome for passing BBB. It can be concluded that the development of liposomes and noisome for brain delivery are still in their infancy, although these systems have the potential to revolutionize the ways in which medicine is ordered.

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Introduction: Glioblastoma multiforme is known as an aggressive brain tumor that is characterized by a high rate of recurrence. Current treatment strategies are not effective for GBM; therefore, novel targeted therapeutic options are urgently required. Nanocarrier-based drug delivery has recently gained attention due to the characteristics of blood-brain barrier permeability, continued drug release, improved solubility, and enhanced drug bioactivity. To this point, we investigated the superior effect of a nano-form of curcumin vs. free-form on the secretion of pro-inflammatory cytokines profile (i.e., IL6 and TNF-α) in the U87 cell line. Materials and Methods: The U87 cell line was purchased from the Iranian Biological Resource Center and expanded in the DMEM/F12 media with 10% FBS and 1% Pen/Strep. To synthesize nanoniosome containing curcumin, the thin-film hybridization method was used. To evaluate the production of IL6 and TNF-α by ELISA method, U87 cells were treated with 84.87 µg/ml of Nano-curcumin and 47 µg/ml of free curcumin. Results: Our results indicated that the production of IL6 and TNF-α was significantly decreased when treated with nano-form and free curcumin. Interestingly, we observed that nano-curcumin could significantly inhibit the secretion of IL6 and TNF-α compared to the curcumin group. Conclusion: The most obvious finding to emerge from this study is that nano-curcumin exerts antiimflammatory effects on glioblastoma.