The Neuroscience Journal of Shefaye Khatam
مجله علوم اعصاب شفای خاتم
Shefaye Khatam
Medical Sciences
http://shefayekhatam.ir
1
admin
2322-1887
2345-4814
10.61186/shefa
fa
jalali
1396
1
1
gregorian
2017
4
1
5
2
online
1
fulltext
en
P 98: Neuroinflammation and Nanomedicine,How about Cerebral Palsy
P 98: Neuroinflammation and Nanomedicine,How about Cerebral Palsy
تحقیقات پایه در علوم اعصاب
Basic research in Neuroscience
مروری
Review --- Open Access, CC-BY-NC
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<p style="font-size: 12px; margin-top: 0px; margin-bottom: 0px; text-align: center;"><span style="color: rgb(0, 0, 0); font-size: 12px; line-height: 20.8px;">لطفاً به چکیده انگلیسی مراجعه شود.</span></p>
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<p>Cerebral palsy (CP) is the most common motor disability in children, usually occurring during fetal development; before, during, or shortly after birth, or during infancy. CP takes place in about 2.1 per 1,000 live births .There is no exact reason but birth injury or inflammation of the central nervous system, infections and hypoxia are related risk factors of this disease. Often, symptoms include poor coordination, stiff muscles, weak muscles, and tremors and they may have impairment of sensation, vision, and hearing, swallowing, and speaking. .In fact treating CP is complex, but in some ways like nanomedicine we can manage the treatment and attenuating the symptoms. Nanomedicine is a branch of medicine that uses nanoparticles and nanodevices like dendimers in diagnosis and treatment of diseases. One of them is neurodegenarative diseases that are always accompaind by neuroinflammation. There is a blood brain barrier (BBB) in CNS to prevent entering micro organisms or something like drugs so we need something to overcome this barrier (BBB) and start diagnosis or treatment of diseases like CP. The aim of this study is looking into the use of nanomedicine in CP and providing a new way without any side effect for treatment of CP. Studies on animal models show that by nanomedicine we can overcome BBB, make drugs available and treat just the area of the brain that is involved in CP , also we can apply it for diagnosis but in some studies there was a toxic effect of nonomaterial so it is offered we can make new particles or devices by material from our own body that can be absorbed fast but with out any side effect or any change in its structure when it is binded to drugs to get the best effect and generalize it for human.</p>
Cerebral palsy, Nanomedicine, Blood brain barrier
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http://shefayekhatam.ir/browse.php?a_code=A-10-24-948&slc_lang=en&sid=1
Soheila
Seddighi
Soheila
Seddighi
sedighis931@mums.ac.ir
100319475328460012100
100319475328460012100
Yes
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran