en O13: Human Neural Stem/Progenitor Cells Derived from Epileptic Human Brain in A Self-Assembling Peptide Nanoscaffold Attenuates Neuroinlammation in Traumatic Brain Injury in Rats تحقیقات پایه در علوم اعصاب Basic research in Neuroscience پژوهشي Research --- Open Access, CC-BY-NC <div style="text-align: center;"><span style="text-align: center; color: rgb(0, 0, 0); text-transform: none; text-indent: 0px; letter-spacing: normal; font-family: Tahoma; font-size: 12px; font-style: normal; font-weight: 400; word-spacing: 0px; float: none; display: inline !important; white-space: normal; orphans: 2; widows: 2; background-color: rgb(251, 250, 249); font-variant-ligatures: normal; font-variant-caps: normal; -webkit-text-stroke-width: 0px; text-decoration-style: initial; text-decoration-color: initial;">لطفاً به چکیده انگلیسی مراجعه شود.</span></div> <div style="text-align: justify;">Traumatic brain injury (TBI) is a disruption in the brain functions following a head trauma. Cell therapy may provide a promising treatment for TBI. Human neural stem cells cultured in self-assembling peptide scaffolds have been proposed as a potential novel method for cell replacement treatment after TBI. In the present study, we accessed the effects of human neural stem/progenitor cells (hNS/PCs) derived from epileptic human brain and human adipose-derived stromal/stem cells (hADSCs) cultured in the RADA16 on brain function after TBI. hNS/PCs were isolated from patients with medically intractable epilepsy undergone epilepsy surgery. hNS/PCs and hADSCs have the potential for proliferation and differentiation into both neuronal and glial lineages. Transplantation of hNS/PCs and hADSCs encapsulated in the PM inhibited neuroinflammation, and reduced the reactive gliosis at the injury site of TBI. The data suggest the transplantation of human stem cells encapsulated in the PM as a hopeful treatment option for cell therapy in TBI.<br> &nbsp;</div> Tissue Engineering, Human Neural Stem Cells, Traumatic Brain Injury 13 13 http://shefayekhatam.ir/browse.php?a_code=A-10-24-1078&slc_lang=en&sid=1 Ali Jahanbazi Jahan-Abad Ali Jahanbazi Jahan-Abad 100319475328460015382 100319475328460015382 No a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran b. Department of Clinical Biochemistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran b. Department of Clinical Biochemistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran Sajad Sahab Negah Sajad Sahab Negah 100319475328460015383 100319475328460015383 No a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran b. Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran b. Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Hassan Hosseini Ravandi Hassan Hosseini Ravandi 100319475328460015384 100319475328460015384 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Sedigheh Ghasemi Sedigheh Ghasemi 100319475328460015385 100319475328460015385 No Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Walter Stummer Walter Stummer 100319475328460015386 100319475328460015386 No Department of Neurosurgery, Westfälische Wilhelms-Universität Münster, Münster, Germany Department of Neurosurgery, Westfälische Wilhelms-Universität Münster, Münster, Germany Ali Gorji Ali Gorji gorjial@uni-muenster.de 100319475328460015387 100319475328460015387 Yes a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran b. Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran c. Department of Neurosurgery, Westfälische Wilhelms-Universität Münster, Münster, Germany d. Epilepsy Research Center, Westfälische Wilhelms-Universität Münster, Münster, Germany a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran b. Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran c. Department of Neurosurgery, Westfälische Wilhelms-Universität Münster, Münster, Germany d. Epilepsy Research Center, Westfälische Wilhelms-Universität Münster, Münster, Germany Maryam Khaleghi Ghadiri Maryam Khaleghi Ghadiri 100319475328460015388 100319475328460015388 No Department of Neurosurgery, Westfälische Wilhelms-Universität Münster, Münster, Germany Department of Neurosurgery, Westfälische Wilhelms-Universität Münster, Münster, Germany