The Neuroscience Journal of Shefaye Khatam
مجله علوم اعصاب شفای خاتم
Shefaye Khatam
Medical Sciences
http://shefayekhatam.ir
1
admin
2322-1887
2345-4814
10.61186/shefa
fa
jalali
1397
1
1
gregorian
2018
4
1
6
2
online
1
fulltext
en
P106: Interleukin-1 Beta; A Forgotten Piece of MS Puzzle Target Therapy
P106: Interleukin-1 Beta; A Forgotten Piece of MS Puzzle Target Therapy
تحقیقات پایه در علوم اعصاب
Basic research in Neuroscience
مروری
Review --- Open Access, CC-BY-NC
<div style="text-align: center;"><span style="background: rgb(251, 250, 249);"><span style="color: black;"><span style="font-family: tahoma,sans-serif;"><span style="font-size: 9pt;">لطفاً به چکیده انگلیسی مراجعه شود</span></span></span></span><span dir="LTR" style="background: rgb(251, 250, 249);"><span style="color: black;"><span style="font-family: tahoma,sans-serif;"><span style="font-size: 9pt;">.</span></span></span></span></div>
<div style="text-align: justify;">Multiple sclerosis (MS) is an inflammatory autoimmune disease which is presented by environmental factors and genetic predisposition, increasingly affecting a large number of people worldwide. CNS inflammation is a local tissue response to stimulants and is characterized by induction of cytokines, chemokines and vascular permeability. Our goal in this study is to understand the micro-environment and immunopathogenesis in neurobiology of MS. A group of cytokines such as Interleukin-1 (IL-1), play an important role in MS pathogenesis. In spite of the fact that IL-1β is a pro-inflammatory cytokine and a mediator responding to inflammation of the nerves, but it’s role in chronic pathophysiologic conditions isn’t well known. IL-1β is mainly secreted from endothelial, T cells, fibroblasts, astrocytes and microglial, meanwhile it is secreted from monocytes, B and T cells as autoimmune mediator in MS patients. So, increment in serum, CSF and CNS lesions level of IL-1β titration in patients is of importance compared with healthy ones. IL-1β is like a sword of two edges, it is secreted from gelial cells in the hypothalamus and activates the neurons, reducing plaque volume. On the other hand, its neuronal excessive expression in MS patients causes severe clinical symptoms, apoptosis of the neurons and the loss of axons and myelin sheath. According to failure in several therapeutics based strategy, MS progression has been remained as a dilemma, leading clinical researchers look for novel agents for target therapy in MS immuonopathogenesis and microenvironment.</div>
IL-1β, Target Therapy, Multiple Sclerosis, Neuroinflammation
137
137
http://shefayekhatam.ir/browse.php?a_code=A-10-24-1092&slc_lang=en&sid=1
Elham
Nouri
Elham
Nouri
100319475328460015867
100319475328460015867
No
Faculty of Paramedicine, Zanjan University of Medical Sciences, Zanjan, Iran
Faculty of Paramedicine, Zanjan University of Medical Sciences, Zanjan, Iran
Abdolreza
Esmaeilzadeh
Abdolreza
Esmaeilzadeh
a46reza@zums.ac.ir
100319475328460015868
100319475328460015868
Yes
Cancer Gene Therapy Research Center (CGRC), Zanjan University of Medical Sciences, Zanjan, Iran
Cancer Gene Therapy Research Center (CGRC), Zanjan University of Medical Sciences, Zanjan, Iran