en P107: Using Nano Particles as a Novel Application for Alzheimer’s Disease; an Effective Endeavor for Drug Delivery تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <div style="text-align: center;"><span style="background: rgb(251, 250, 249);"><span style="color: black;"><span style="font-family: tahoma,sans-serif;"><span style="font-size: 9pt;">لطفاً به چکیده انگلیسی مراجعه شود</span></span></span></span><span dir="LTR" style="background: rgb(251, 250, 249);"><span style="color: black;"><span style="font-family: tahoma,sans-serif;"><span style="font-size: 9pt;">.</span></span></span></span></div> <div style="text-align: justify;">As the most common cause of dementia among the elderly results in cognitive and &lrm;behavioral impairment, Alzheimer&rsquo;s disease (AD) is characterized with aggregation of senile &lrm;plaques (Beta-amyloid protein), cortical atrophy and ventricular enlargement. Unfortunately, &lrm;conventional methods like acetyl cholinesterase inhibitor drugs, are not so effective owing to &lrm;restrictive mechanisms imposed at the blood&ndash;brain barrier (BBB), poor solubility, and low &lrm;bioavailability. So, researchers show a tendency towards using Nano technological methods &lrm;involving application of nanoscale drug delivery system through polymeric nanoparticles, &lrm;microemulsion, solid lipid nanoparticles, nanostructured lipid carriers, nanoemulsion, and liquid &lrm;crystals. As drug delivery agents, Nanoparticles are solid colloidal particles ranging in size from 1 &lrm;to 1000 nm that mask the BBB limiting characteristics. This system may slow drug release in the &lrm;brain, decreasing collateral damage and peripheral toxicity. They have high drug loading &lrm;capacities that is capable of targeting towards the mutagenic proteins of AD. Biodegradable &lrm;nanoparticles such as PLGA, PLA, chitosan gelatin, polycaprolactone and poly-alkyl-&lrm;cyanoacrylates have been used frequently as drug delivery vehicles due to its grand &lrm;bioavailability, better encapsulation and less toxic properties. These carriers can deliver drugs that &lrm;proved to have anti-Alzheimer effect, such as: clioquinol derived from quinoline known to &lrm;solubilize the A-Beta plaques in vitro and inhibits the A-Beta accumulation in AD transgenic &lrm;mice in vivo, D-Penicillamine conjugated to NPs seem to reverse the metal-induced precipitation &lrm;&lrm;(specially Cu2+) and decreases the beta amyloid protein concentration. A robust &lrm;collaboration between specialists and medical nanotechnology researchers opens promising &lrm;windows to AD dilemma.&lrm;</div> Nano Particles, Alzheimer’s Disease, Drug Delivery 138 138 http://shefayekhatam.ir/browse.php?a_code=A-10-24-1095&slc_lang=en&sid=1 Mohammad Javad Hajkazemi Mohammad Javad Hajkazemi 100319475328460015869 100319475328460015869 No Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Abdolreza Esmaeilzadeh Abdolreza Esmaeilzadeh a46reza@zums.ac.ir 100319475328460015870 100319475328460015870 Yes Department of Immunology, Zanjan University of Medical Sciences, Zanjan, Iran Department of Immunology, Zanjan University of Medical Sciences, Zanjan, Iran