en P111: Effect of Human Neural Stem Cells on Neural Hyperactivity in Kindeling Rat Models تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <div style="text-align: center;"><span style="background:#FBFAF9;"><span style="color:black;"><span style="font-family:tahoma,sans-serif;"><span style="font-size:9.0pt;">لطفاً به چکیده انگلیسی مراجعه شود</span></span></span></span><span dir="LTR" style="background:#FBFAF9;"><span style="color:black;"><span style="font-family:tahoma,sans-serif;"><span style="font-size:9.0pt;">.</span></span></span></span></div> <div style="text-align: justify;">The excessive electrical activity of neurons is reported in many diseases including: Parkinson&#39;s disease, Alzheimer&#39;s disease, and Epilepsy. Electrical overactivity in hippocampus accelerates the depletion of neural stem cell (NSC) and impairs the neurogenesis in hippocampus. It is believed that neurogenesis in hippocampus improves the cognitive functions. In this experiment, we use kindled model of rats to represent the hyperactivity of neurons, using the repeated weak excitation of brain structures that progressively increases sensitivity to the same stimulation. At the end, we will compare the NSC group, vehicle group (which get the resolvent of NSCs), and control group by considering their immunohistochemistry and western blotting samples of each group. Cognitive function and neurogenesis in the hippocampus will be evaluated. Our data probably show that the NSCs can improve the function of the hyperactivated brain and can reduce the complications and impairments due to the hyperactivated neural diseases by change in rat&#39;s EEG and field potential record.</div> Human Neural Stem Cell, Neural Hyperactivity, Kindeling 142 142 http://shefayekhatam.ir/browse.php?a_code=A-10-24-1104&slc_lang=en&sid=1 Zahra Gharaeian Morshed Zahra Gharaeian Morshed 100319475328460015876 100319475328460015876 No Department of Neuroscience, Mashhad University of Medical Science, Mashhad, Iran Department of Neuroscience, Mashhad University of Medical Science, Mashhad, Iran Zinat Heidarnia Zinat Heidarnia 100319475328460015877 100319475328460015877 No Department of Physiology, Sabzevar University of Medical Science, Sabzevar, Iran Department of Physiology, Sabzevar University of Medical Science, Sabzevar, Iran Mohammad Mohammadzadeh Mohammad Mohammadzadeh 100319475328460015878 100319475328460015878 No Department of Physiology, Mashhad University of Medical Science, Mashhad, Iran Department of Physiology, Mashhad University of Medical Science, Mashhad, Iran Sajad Sahab Negah Sajad Sahab Negah sahabnegahs@mums.ac.ir 100319475328460015879 100319475328460015879 Yes Department of Neuroscience, Mashhad University of Medical Science, Mashhad, Iran Department of Neuroscience, Mashhad University of Medical Science, Mashhad, Iran