en W4: Cancer Stem Cells as a New Target Point for Treatment of Glioblastoma تحقیقات پایه در علوم اعصاب Basic research in Neuroscience پژوهشي Research --- Open Access, CC-BY-NC &nbsp; <table border="0" cellpadding="5" cellspacing="2" dir="rtl" id="table_article" style="text-transform: none; text-indent: 0px; letter-spacing: normal; font-family: Tahoma; word-spacing: 0px; orphans: 2; widows: 2; break-inside: avoid !important; background-color: rgb(251, 250, 249); -webkit-text-stroke-width: 0px; text-decoration-style: initial; text-decoration-color: initial;" width="100%"> <tbody style="text-align: justify; line-height: 2.2; font-size: 12px; margin-top: 0px; margin-bottom: 0px; break-inside: avoid !important;"> <tr style="break-inside: avoid !important;"> <td class="abstractmed" colspan="2" style="text-align: justify; break-inside: avoid !important;"> <p style="text-align: center; font-size: 12px; margin-top: 0px; margin-bottom: 0px;"><span style="text-align: center; color: rgb(0, 0, 0); font-family: Tahoma; font-size: 12px; background-color: rgb(251, 250, 249);">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> </td> </tr> <tr style="break-inside: avoid !important;"> </tr> </tbody> </table> <p style="text-align: justify;">Glioblastoma is a destructive form of brain tumor that kills most patients within two years of diagnosis.Treatments for glioblastoma include the usual options of surgery, radiation therapy and chemotherapy, but there is no effective treatment. The tumors are capable of spreading tendrils out into the brain and it can grow back in a matter of months after being removed.&nbsp;The cancer stem cell (CSC) provides an alternative model to explain the tumor cell heterogeneity. CSCs are thought to be the less differentiated populations in malignant tissues and are considered to be the cells that are responsible for the maintenance of tumor tissues, as well as for the relapse of tumors after conventional treatment. This review provided the confirmation for the presence of CSCs in primary tumors. The CSC hypothesis raises the expectation that targeting of CSCs in tumors will lead to an improved clinical outcome because they are thought to be the &lsquo;&lsquo;root&rsquo;&rsquo; of growing tumors.</p> Glioblastoma, Cancer Stem Cells, Treatment 31 31 http://shefayekhatam.ir/browse.php?a_code=A-10-24-1109&slc_lang=en&sid=1 Sajad Sahab Negah Sajad Sahab Negah sahabnegahs@mums.ac.ir 100319475328460015434 100319475328460015434 Yes A. Neuroscience Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran B. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran A. Neuroscience Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran B. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Sara Pasban Bovanlo Sara Pasban Bovanlo 100319475328460015435 100319475328460015435 No Neuroscience Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Neuroscience Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Fatemeh Ariakia Fatemeh Ariakia 100319475328460015436 100319475328460015436 No Neuroscience Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Neuroscience Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran