en P12: Protective Effects of Nigella Sativa on Synaptic Plasticity Impairment Induced by Lipopolysaccharide تحقیقات پایه در علوم اعصاب Basic research in Neuroscience پژوهشي Research --- Open Access, CC-BY-NC &nbsp; <table border="0" cellpadding="5" cellspacing="2" dir="rtl" id="table_article" style="text-transform: none; text-indent: 0px; letter-spacing: normal; font-family: Tahoma; word-spacing: 0px; orphans: 2; widows: 2; break-inside: avoid !important; background-color: rgb(251, 250, 249); -webkit-text-stroke-width: 0px; text-decoration-style: initial; text-decoration-color: initial;" width="100%"> <tbody style="text-align: justify; line-height: 2.2; font-size: 12px; margin-top: 0px; margin-bottom: 0px; break-inside: avoid !important;"> <tr style="break-inside: avoid !important;"> <td class="abstractmed" colspan="2" style="text-align: justify; break-inside: avoid !important;"> <p style="text-align: center; font-size: 12px; margin-top: 0px; margin-bottom: 0px;"><span style="text-align: center; color: rgb(0, 0, 0); font-family: Tahoma; font-size: 12px; background-color: rgb(251, 250, 249);">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> </td> </tr> <tr style="break-inside: avoid !important;"> </tr> </tbody> </table> <p style="text-align: justify;">In the present study the protective effect of Nigella sativa (N. sativa) on synaptic plasticity impairment induced by lipopolysaccharide (LPS) in rats was investigated. Fifty-eight rats were grouped and treated as follows: 1) control (saline), 2) LPS, 3) LPS-N. sativa, and 4) N. sativa. In a Morris water maze test, the escape latency and travelled path to find the platform as well as time spent and the travelled distance in target quadrant (Q1) were measured. Long term potentiation (LTP) from CA1 area of hippocampus followed by high frequency stimulation to Schafer collateral was studied and slope, slope 10-90% and amplitude of field excitatory field potential (fEPSP) were calculated. The escape latency and traveled path in LPS group were significantly higher than those in the control group while, in LPS-N. sativa group these parameters were significantly lower than those in LPS group. The rats in LPS group spent less time and travelled shorter distance in Q1 than the rats in the control group while, in LPS-N. sativa group the rats spent more time and travelled longer distance than the rats in LPS group. LPS significantly decreased slope, slope 10-90% and amplitude of fEPSP while, in LPS-N. sativa group these parameters increased compared to LPS group. The results indicated that the hydro-alcohol extract of N. sativa protected against synaptic plasticity and spatial learning and memory impairment induced by LPS in rats.</p> Lipopolysaccharide, Long Term Potentiation, Nigella Sativa L, Spatial Memory, Synaptic Plasticity 43 43 http://shefayekhatam.ir/browse.php?a_code=A-10-24-1129&slc_lang=en&sid=1 Farimah Beheshti Farimah Beheshti 100319475328460015487 100319475328460015487 No a. Department of Basic Sciences and Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran b. Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran a. Department of Basic Sciences and Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran b. Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Akbar Anaeigoudari Akbar Anaeigoudari 100319475328460015488 100319475328460015488 No Department of Basic Sciences and Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran Department of Basic Sciences and Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran Fatemeh Norouzi Fatemeh Norouzi 100319475328460015489 100319475328460015489 No Department of Physiology, Esfarayan University of Medical Sciences, Esfarayan, Iran Department of Physiology, Esfarayan University of Medical Sciences, Esfarayan, Iran Azam Abareshi Azam Abareshi 100319475328460015490 100319475328460015490 No Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran Mohammad Naser Shafei Mohammad Naser Shafei 100319475328460015491 100319475328460015491 No Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Zahra Gholamnezhad Zahra Gholamnezhad 100319475328460015492 100319475328460015492 No Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Mahmoud Hosseini Mahmoud Hosseini hosseinim@mums.ac.i 100319475328460015493 100319475328460015493 Yes Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran