en P121: The Effect of Stress on Neuroinflammation in Multiple Sclerosis تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <div style="text-align: center;"><span style="background:#FBFAF9;"><span style="color:black;"><span style="font-family:tahoma,sans-serif;"><span style="font-size:9.0pt;">لطفاً به چکیده انگلیسی مراجعه شود</span></span></span></span><span dir="LTR" style="background:#FBFAF9;"><span style="color:black;"><span style="font-family:tahoma,sans-serif;"><span style="font-size:9.0pt;">.</span></span></span></span></div> <div style="text-align: justify;">Multiple sclerosis (MS) is a chronic autoimmune disorder of central nervous system. This demyelinating disease affects more than 2.3 million people world wild. Most of patients are young adult. There are many possible triggering factors including infections, toxin, immunization, trauma, sunlight exposure and hormonal variable in pathogenesis of MS. One of the important trigger is stress. There are some substantial evidence that indicates stress can precipitate or worsen symptoms and sign of inflammation in general and more specifically in multiple sclerosis. This review has focused on elucidating the effect of stress on neuroinflammation in multiple sclerosis. The mechanism of stress in MS is not completely understood. There are some proposed theories such as secretion of Corticotropin Relapsing Hormone (CRH) and neurotinensin (NT). These inflammatory factors activate microglia and mast cells leading to maturation and activation of T17 autoimmune cells. Disruption of Blood Brain Barrier (BBB) cause T17 cells to enter in to the CNS. Finally brain inflammation will be worsened. The pathway of stress neuroinflammation can be considered as a therapeutic target for M.S patients. Some evidences indicate Glatiramer Acetat, stress management therapy, Diazepam, Alprazolam and CRH antagonists can reduce brain inflammation So the mechanism of stress in pathogenesis of M.S can be novel therapeutic target.</div> Stress, Neuroinflammation, Multiple Sclerosis 152 152 http://shefayekhatam.ir/browse.php?a_code=A-10-24-1130&slc_lang=en&sid=1 Zahra Behrooznia Zahra Behrooznia z.behrooznia@gmail.com 100319475328460015902 100319475328460015902 Yes Student Research Committee, Faculty of Medicine, Islamic Azad University of Mashhad, Mashhad, Iran Student Research Committee, Faculty of Medicine, Islamic Azad University of Mashhad, Mashhad, Iran Masoud Kashani Lotf Abadi Masoud Kashani Lotf Abadi 100319475328460015903 100319475328460015903 No Psychiatry and Behavioral Research Center, Ibn-e-Sina Hospital, Mashhad University of Medical Sciences, Mashhad, Iran Psychiatry and Behavioral Research Center, Ibn-e-Sina Hospital, Mashhad University of Medical Sciences, Mashhad, Iran Somayyeh Behrooznia Somayyeh Behrooznia 100319475328460015904 100319475328460015904 No Department of Psychology, Hakim Toos University, Mashhad, Iran Department of Psychology, Hakim Toos University, Mashhad, Iran Pouya Ghaderi Pouya Ghaderi 100319475328460015905 100319475328460015905 No Student Research Committee, Faculty of Medicine, Islamic Azad University of Mashhad, Mashhad, Iran Student Research Committee, Faculty of Medicine, Islamic Azad University of Mashhad, Mashhad, Iran