en P15: Mephedrone Exposure in Pegnancy Iinduces Antiprolifrative and Proapoptotic Effects in Hippocampus of Mice Delivered Pups تحقیقات پایه در علوم اعصاب Basic research in Neuroscience پژوهشي Research --- Open Access, CC-BY-NC &nbsp; <table border="0" cellpadding="5" cellspacing="2" dir="rtl" id="table_article" style="text-transform: none; text-indent: 0px; letter-spacing: normal; font-family: Tahoma; word-spacing: 0px; orphans: 2; widows: 2; break-inside: avoid !important; background-color: rgb(251, 250, 249); -webkit-text-stroke-width: 0px; text-decoration-style: initial; text-decoration-color: initial;" width="100%"> <tbody style="text-align: justify; line-height: 2.2; font-size: 12px; margin-top: 0px; margin-bottom: 0px; break-inside: avoid !important;"> <tr style="break-inside: avoid !important;"> <td class="abstractmed" colspan="2" style="text-align: justify; break-inside: avoid !important;"> <p style="text-align: center; font-size: 12px; margin-top: 0px; margin-bottom: 0px;"><span style="text-align: center; color: rgb(0, 0, 0); font-family: Tahoma; font-size: 12px; background-color: rgb(251, 250, 249);">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> </td> </tr> <tr style="break-inside: avoid !important;"> </tr> </tbody> </table> <p style="text-align: justify;">In recent years, abuse of synthetic cathinones, in particular, mephedrone, has increased among young adults worldwide. The study aim is to investigate the effects of mephedrone exposure during the gestational period on mice offspring outcomes, focusing on hippocampal neurotoxicity. The pregnant mice received mephedrone (50mg/kg, sc) on a regular schedule (once daily on all days, from day 5 to 18 of gestation) or repeated schedule (thrice daily on day 5, 6, 11, 12, 17, and 18 of gestation) to simulate regular or recreational use of mephedrone, respectively. Immunohistochemistry and TUNEL assay showed an inhibition of cell proliferation (p<0.05) and an increase of apoptosis (p<0.05) in the hippocampus of delivered pups of the repeated schedule mephedrone group. In conclusion, the present study has shown that repeated use of mephedrone impairs learning and memory processes through hippocampal damage.</p> Hippocampus, Mice, Memory 46 46 http://shefayekhatam.ir/browse.php?a_code=A-10-24-1138&slc_lang=en&sid=1 Gholamreza Naseri Gholamreza Naseri g_naseri@yahoo.com 100319475328460015498 100319475328460015498 Yes Department of Anatomy and Cellular Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Department of Anatomy and Cellular Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Alireza Fazel Alireza Fazel 100319475328460015499 100319475328460015499 No Department of Anatomy and Cellular Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Department of Anatomy and Cellular Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Mohammad Jafar Golalipour Mohammad Jafar Golalipour 100319475328460015500 100319475328460015500 No Gorgan Congenital Malformations Research Center, Golestan University of Medical Sciences, Gorgan, Iran Gorgan Congenital Malformations Research Center, Golestan University of Medical Sciences, Gorgan, Iran Hossein Haghir Hossein Haghir 100319475328460015501 100319475328460015501 No Department of Anatomy and Cellular Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Department of Anatomy and Cellular Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Hamid Sadeghian Hamid Sadeghian 100319475328460015502 100319475328460015502 No Department of Laboratory Sciences, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran Department of Laboratory Sciences, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran Majid Mojarrad Majid Mojarrad 100319475328460015503 100319475328460015503 No a. Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran b. Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran a. Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran b. Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Mahmoud Hosseini Mahmoud Hosseini 100319475328460015504 100319475328460015504 No Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Shokouh Shahrokhi Sabzevar Shokouh Shahrokhi Sabzevar 100319475328460015505 100319475328460015505 No Department of Basic Science and Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran Department of Basic Science and Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran Farimah Beheshti Farimah Beheshti 100319475328460015506 100319475328460015506 No Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran Ahmad Ghorbani Ahmad Ghorbani 100319475328460015507 100319475328460015507 No Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran