en P132: Efficacy of Crocin as Anti-Inflammatory Agent in Multiple Sclerosis Patients تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <div style="text-align: center;"><span style="background:#FBFAF9;"><span style="color:black;"><span style="font-family:tahoma,sans-serif;"><span style="font-size:9.0pt;">لطفاً به چکیده انگلیسی مراجعه شود</span></span></span></span><span dir="LTR" style="background:#FBFAF9;"><span style="color:black;"><span style="font-family:tahoma,sans-serif;"><span style="font-size:9.0pt;">.</span></span></span></span></div> <div style="text-align: justify;">Inflammations form an integral part of the innate immunity against pathogenic infections. NF-&kappa;B represents a family of inducible transcription factors, which regulates a large array of genes involved in different processes of the immune and inflammatory responses. It is now clear that NF-&kappa;B signaling pathway is involved in the regulation of inflammation, contributing to the initiation and development of inflammatory diseases. One of inflammatory disease is multiple sclerosis, which is the CNS generally considered to be an autoimmune disease involving the pathogenic action of CNS-specific CD4+ T cells, particularly Th1 and Th17 cells. Normally, inflammation is beneficial to the host and can be resolved in a timely manner. Saffron in filaments is the dried, dark red stigmata of Crocus sativus L. flowers and it is used as a spice, food colorant, and a drug in medicine. Crocin is the chemical primarily responsible for the color of saffron. In additional to reduce the TNFR1 protein expression, decrease of p-I&kappa;B protein levels and thus confirming an early inactivation of NF-&kappa;B so it&rsquo;s useful as anti-inflammatory drugs.</div> Crocin, Multiple Sclerosis, NF-κB, TNFR1 163 163 http://shefayekhatam.ir/browse.php?a_code=A-10-24-1152&slc_lang=en&sid=1 Sadra Habbibirad Sadra Habbibirad habibiradsadra90@gmail.com 100319475328460015927 100319475328460015927 Yes Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Hoda Kashani Hoda Kashani 100319475328460015928 100319475328460015928 No Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Meysam Gachpazan Meysam Gachpazan 100319475328460015929 100319475328460015929 No a. Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran b. Student Research Committee, Department of Modern Sciences & Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran a. Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran b. Student Research Committee, Department of Modern Sciences & Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Hamid Reza Rahimi Hamid Reza Rahimi 100319475328460015930 100319475328460015930 No Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran