The Neuroscience Journal of Shefaye Khatam

en P133: Targeting NF-Κb Signaling Pathway as Potential Therapeutic with Curcumin in Treatment of Multiple Sclerosis P133: Targeting NF-Κb Signaling Pathway as Potential Therapeutic with Curcumin in Treatment of Multiple Sclerosis تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <div style="text-align: center;"><span style="background:#FBFAF9;"><span style="color:black;"><span style="font-family:tahoma,sans-serif;"><span style="font-size:9.0pt;">لطفاً به چکیده انگلیسی مراجعه شود</span></span></span></span><span dir="LTR" style="background:#FBFAF9;"><span style="color:black;"><span style="font-family:tahoma,sans-serif;"><span style="font-size:9.0pt;">.</span></span></span></span></div> <div style="text-align: justify;">Curcumin is active component of turmeric and isolated from the rhizome of turmeric, a phenolic natural product. One of inflammatory disease is multiple sclerosis, a multifocal chronic autoimmune inflammatory disease of the CNS, which is also known as a perivascular demyelinating disease. Studies have been shown that neuro-inflammation can have both harmful and beneficial effects on the neuronal and glial cells function, transcription factor nuclear factor-kappa B(NF-κB) has a determinant role in controlling this process. The involvement of NF-κB signaling pathway in multiple sclerosis has been suggested by genome-wide association studies. Selective anti-NF-κB therapeutic strategies could be beneficial for minimizing damages during acute and chronic inflammation. Genes that can be induced by NF-κB signaling include those that encode important molecules such as TNF-α, IL-1, IL-6, SOD, Bcl-2, and inhibitors of apoptosis proteins. Curcumin, have been shown exhibit anti-inflammatory and anti-mutagenic in addition to anti-carcinogenic activity. Downregulation expression of the NF-κB-regulated gene products such as COX-2, TNF, 5-LOX, IL-1, IL-6 and others, inhibition multiple pro-inflammatory pathways.</div> Curcumin, NF-κB, MS, CNS 164 164 http://shefayekhatam.ir/browse.php?a_code=A-10-24-1158&slc_lang=en&sid=1 Meysam Gachpazan Meysam Gachpazan 100319475328460015931 100319475328460015931 No a. Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran b. Department of Modern Sciences & Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran a. Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran b. Department of Modern Sciences & Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Sadra Habbibirad Sadra Habbibirad 100319475328460015932 100319475328460015932 No Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Hoda Kashani Hoda Kashani 100319475328460015933 100319475328460015933 No Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Hamid Reza Rahimi Hamid Reza Rahimi gachpazanm961@mums.ac.ir 100319475328460015934 100319475328460015934 Yes Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran