en P32: Effect of Airway Pressure Release Ventilation Mode on Intracranial Pressure and Oxygenation in Patients with Traumatic Brain Injuries تحقیقات پایه در علوم اعصاب Basic research in Neuroscience پژوهشي Research --- Open Access, CC-BY-NC &nbsp; <table border="0" cellpadding="5" cellspacing="2" dir="rtl" id="table_article" style="text-transform: none; text-indent: 0px; letter-spacing: normal; font-family: Tahoma; word-spacing: 0px; orphans: 2; widows: 2; break-inside: avoid !important; background-color: rgb(251, 250, 249); -webkit-text-stroke-width: 0px; text-decoration-style: initial; text-decoration-color: initial;" width="100%"> <tbody style="text-align: justify; line-height: 2.2; font-size: 12px; margin-top: 0px; margin-bottom: 0px; break-inside: avoid !important;"> <tr style="break-inside: avoid !important;"> <td class="abstractmed" colspan="2" style="text-align: justify; break-inside: avoid !important;"> <p style="text-align: center; font-size: 12px; margin-top: 0px; margin-bottom: 0px;"><span style="text-align: center; color: rgb(0, 0, 0); font-family: Tahoma; font-size: 12px; background-color: rgb(251, 250, 249);">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> </td> </tr> <tr style="break-inside: avoid !important;"> </tr> </tbody> </table> <p style="text-align: justify;">This study aimed at compare influences of airway pressure release ventilation (APRV) and Synchronized Intermittent Mechanical Ventilation (SIMV) on intracranial pressure and oxygenation status in patients with traumatic brain injuries. A clinical trial was carried out in 40 patients with traumatic brain injuries in the intensive care unit in Kamyab neurosurgery Hospital, Mashhad, Iran. The patients meeting the study inclusion criteria were randomly assigned into two groups; intervention (APRV, n= 20) and control (SIMV, n= 20). The ICP, CPP, MAP, PaO2, SPO2, PaO2/FIO2 in both groups were measured before and after conditioning. Analysis of data was done using independent t-test in SPSS V.22. The mean ICP remained unchanged in both groups (P= 0.421). After the intervention, the CPP, MAP, heart rate, and pulse pressure in APRV group were not significantly different compared with those in the two groups before the intervention (P> 0.05), PaO2, SPO2, PaO2/FIO2 in APRV group were significantly improved. The results showed APRV as a safe mode that can be beneficial in patients with traumatic brain injury without concerns for increased intracranial pressure.</p> Traumatic Brain Injury, Intracranial Pressure, Airway Pressure Release Ventilation, Oxygenation 63 63 http://shefayekhatam.ir/browse.php?a_code=A-10-24-1169&slc_lang=en&sid=1 Javad Malekadeh Javad Malekadeh 100319475328460016113 100319475328460016113 No Department of Medical Emergency, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran Department of Medical Emergency, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran Aliyeh Pasandideh Khajebeyk Aliyeh Pasandideh Khajebeyk pasandidea1@mums.ac.ir 100319475328460016114 100319475328460016114 Yes School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran Reza Mazlum Seyyed Reza Mazlum 100319475328460016115 100319475328460016115 No Department of Medical Surgical Nursing, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran Department of Medical Surgical Nursing, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran Mahbube Yazdani Mahbube Yazdani 100319475328460016116 100319475328460016116 No School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran