en P37: Decreased Serum Levels of Interleukin-35 Among Patients with Relapsing Remitting Multiple Sclerosis تحقیقات پایه در علوم اعصاب Basic research in Neuroscience پژوهشي Research --- Open Access, CC-BY-NC &nbsp; <table border="0" cellpadding="5" cellspacing="2" dir="rtl" id="table_article" style="text-transform: none; text-indent: 0px; letter-spacing: normal; font-family: Tahoma; word-spacing: 0px; orphans: 2; widows: 2; break-inside: avoid !important; background-color: rgb(251, 250, 249); -webkit-text-stroke-width: 0px; text-decoration-style: initial; text-decoration-color: initial;" width="100%"> <tbody style="text-align: justify; line-height: 2.2; font-size: 12px; margin-top: 0px; margin-bottom: 0px; break-inside: avoid !important;"> <tr style="break-inside: avoid !important;"> <td class="abstractmed" colspan="2" style="text-align: justify; break-inside: avoid !important;"> <p style="text-align: center; font-size: 12px; margin-top: 0px; margin-bottom: 0px;"><span style="text-align: center; color: rgb(0, 0, 0); font-family: Tahoma; font-size: 12px; background-color: rgb(251, 250, 249);">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> </td> </tr> <tr style="break-inside: avoid !important;"> </tr> </tbody> </table> <p style="text-align: justify;">The regulatory role of interleukin-35 (IL-35) in the immunopathogenesis of multiple sclerosis (MS) is suggested in very few studies. We aimed to measure serum levels of IL-35 among clinically isolated syndrome (CIS) and relapsing-remitting MS (RRMS) patients and evaluate the associations between this cytokine and the disease clinical course. This cross-sectional study was conducted during 2017 in MS Clinic of Kashani hospital, Isfahan, Iran. Forty patients with the diagnosis of CIS and RRMS according to McDonald criteria were included in the study, as well as 40 healthy controls. Also, data regarding clinical course of the disease was collected from cases. The levels of IL-35 in the serum of all subjects were determined by ELISA. Serum levels of IL-35 were&nbsp;comparison&nbsp;with healthy controls. Moreover, the mean serum levels of IL-35 among new cases (diagnosed within 6 months before the study) were decreased compared to healthy controls but it were not statistically significant (P=0.059).The mean serum levels of IL-35 were significantly higher in new cases compared with other cases (p=0.048). We found decreased serum levels of IL-35 among RRMS patients compared to the healthy controls. We provide a view of the possible role of IL-35 in MS pathogenesis and the potential therapeutic targets in this way.</p> Multiple Sclerosis, Clinically Isolated Syndrome, Relapsing-Remitting Multiple Sclerosis, Interleukin-35 68 68 http://shefayekhatam.ir/browse.php?a_code=A-10-24-1176&slc_lang=en&sid=1 Omid Mirmosayyeb Omid Mirmosayyeb 100319475328460016124 100319475328460016124 No a. Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran b. Students Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran a. Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran b. Students Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Shervin Badihian Shervin Badihian 100319475328460016125 100319475328460016125 No a. Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran b. Students Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran a. Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran b. Students Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Vahid Shaygannejad Vahid Shaygannejad 100319475328460016126 100319475328460016126 No a. Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran b. Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran a. Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran b. Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Parisa Soleimani Parisa Soleimani 100319475328460016127 100319475328460016127 No a. Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran b. Students Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran a. Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran b. Students Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Navid Manouchehri Navid Manouchehri 100319475328460016128 100319475328460016128 No a. Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran b. Students Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran a. Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran b. Students Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Zahra Samee Zahra Samee 100319475328460016129 100319475328460016129 No a. Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran b. Students Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran a. Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran b. Students Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Nafiseh Esmaeil Nafiseh Esmaeil omid.mirmosayyeb@gmail.com 100319475328460016130 100319475328460016130 Yes Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran