en P153: Evaluating the Effect of Lactobacillus Acidophilus Probiotic Supplementation on Sensory-Motor Recovery After a Traumatic Brain Injury تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <div style="text-align: center;"><span style="background:#FBFAF9;"><span style="color:black;"><span style="font-family:tahoma,sans-serif;"><span style="font-size:9.0pt;">لطفاً به چکیده انگلیسی مراجعه شود</span></span></span></span><span dir="LTR" style="background:#FBFAF9;"><span style="color:black;"><span style="font-family:tahoma,sans-serif;"><span style="font-size:9.0pt;">.</span></span></span></span></div> <div style="text-align: justify;">Traumatic brain injury (TBI) is a common cause of death which affects millions of people around the world. TBI is also associated with various neurological impairments. After the primary mechanical injury at the moment of a TBI event, several cellular and molecular processes are activated within the brain tissue as the secondary injury. An important mechanism involved in the secondary injury of TBI is Neuroinflammation. Therefore, neuroinflammation offers a promising avenue for therapeutic intervention with the aim of preventing progressive neurodegeneration and improving the neurological recovery after TBI. A number of studies have shown the efficacy of probiotics in modulating inflammatory responses; however, it is still unclear if probiotics have the ability to regulate neuroinflammation, and more research is needed to determine the effect of probiotics on neuroinflammation and neurological recovery. If proven beneficial, probiotics offer a non-invasive, safe and cheap therapy for regulating post-TBI neuroinflammation. Multiple studies have demonstrated the ability of probiotics in decreasing inflammatory cytokines while also increasing the anti-inflammatory cytokines. Therefore, we hypothesize that using probiotics after TBI may have the capacity to modulate neuroinflammatory response and as a result, improve the neurological recovery.</div> Neuroinflammation, Probiotics, Traumatic Brain Injury, TBI, Sensory-Motor Recovery 184 184 http://shefayekhatam.ir/browse.php?a_code=A-10-24-1201&slc_lang=en&sid=1 Ali Mehri Ali Mehri 100319475328460016207 100319475328460016207 No a. Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran b. Neuroscience Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran a. Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran b. Neuroscience Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Amirhossein Heidari Amirhossein Heidari 100319475328460016208 100319475328460016208 No a. Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran b. Neuroscience Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran a. Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran b. Neuroscience Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Mohammad Moein Vakilzadeh Mohammad Moein Vakilzadeh 100319475328460016209 100319475328460016209 No a. Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran b. Neuroscience Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran a. Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran b. Neuroscience Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Sara Pasban Bovanlo Sara Pasban Bovanlo 100319475328460016210 100319475328460016210 No Neuroscience Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Neuroscience Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Ali Gorji Ali Gorji 100319475328460016211 100319475328460016211 No a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran b. Department of Neurosurgery, Westfälische Wilhelms-Universität Münster, Münster, Germany a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran b. Department of Neurosurgery, Westfälische Wilhelms-Universität Münster, Münster, Germany Sajad Sahab Negah Sajad Sahab Negah sahabnegahs@mums.ac.ir 100319475328460016212 100319475328460016212 Yes a. Neuroscience Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran b. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran a. Neuroscience Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran b. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran