en P54: The Oxidative Stress Assessment of Echium Amoenum on Mice Brain تحقیقات پایه در علوم اعصاب Basic research in Neuroscience پژوهشي Research --- Open Access, CC-BY-NC &nbsp; <table border="0" cellpadding="5" cellspacing="2" dir="rtl" id="table_article" style="text-transform: none; text-indent: 0px; letter-spacing: normal; font-family: Tahoma; word-spacing: 0px; orphans: 2; widows: 2; break-inside: avoid !important; background-color: rgb(251, 250, 249); -webkit-text-stroke-width: 0px; text-decoration-style: initial; text-decoration-color: initial;" width="100%"> <tbody style="text-align: justify; line-height: 2.2; font-size: 12px; margin-top: 0px; margin-bottom: 0px; break-inside: avoid !important;"> <tr style="break-inside: avoid !important;"> <td class="abstractmed" colspan="2" style="text-align: justify; break-inside: avoid !important;"> <p style="text-align: center; font-size: 12px; margin-top: 0px; margin-bottom: 0px;"><span style="text-align: center; color: rgb(0, 0, 0); font-family: Tahoma; font-size: 12px; background-color: rgb(251, 250, 249);">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> </td> </tr> <tr style="break-inside: avoid !important;"> </tr> </tbody> </table> <p style="text-align: justify;">Echium Amoenum (Boraginaceae) is one of the important medicinal herbs in traditional medicine. It has known for its variety effects such as demulcent, anti-inflammatory and analgesic, especially for common cold,&nbsp;anxiolytic and sedative, this plant contains small quantities of pyrrolizidine alkaloids that are toxic and chronic consumption may have adverse effects on the body&#39;s organs. in this study, 60 mice were chosen and divided into four groups. Group (1) as control group (without injection), group (2) received 12.5mg/kg, group (3) received 25mg/kg, group (4) received 50mg/kg body weight&nbsp;plant. Boraginaceae was injected into mice for a month. Then, the mice were decapitated and brains were collected to evaluate oxidative stress. The level of lipid oxidation was significant in groups. Brain tissue is rich in polyunsaturated fatty acid. Therefore, the level of lipid oxidation is usually more than other tissue. Changes in Ion reducing antioxidant capacity assay (CUPRAC) were not significant. The level of glutathione (GSH) increase in high dose. Echium Amoenum may don&rsquo;t trigger toxicity in brain in low and intermediate doses.</p> Echium Amoenum, Oxidative Stress, Brain 85 85 http://shefayekhatam.ir/browse.php?a_code=A-10-24-1206&slc_lang=en&sid=1 Afsaneh Mohajer Afsaneh Mohajer 100319475328460015674 100319475328460015674 No Department of Environmental Health, Food Safety Division, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran Department of Environmental Health, Food Safety Division, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran Atefeh Araghi Atefeh Araghi 100319475328460015675 100319475328460015675 No Department of Food Hygiene, School of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran Department of Food Hygiene, School of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran Parisa Sadighara Parisa Sadighara Parisasss@yahoo.com 100319475328460015676 100319475328460015676 Yes Department of Environmental Health, Food Safety Division, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran Department of Environmental Health, Food Safety Division, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran