en P156: Effect of Air Pollution on Alzheimer's Disease تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <div style="text-align: center;"><span style="background:#FBFAF9;"><span style="color:black;"><span style="font-family:tahoma,sans-serif;"><span style="font-size:9.0pt;">لطفاً به چکیده انگلیسی مراجعه شود</span></span></span></span><span dir="LTR" style="background:#FBFAF9;"><span style="color:black;"><span style="font-family:tahoma,sans-serif;"><span style="font-size:9.0pt;">.</span></span></span></span></div> <div style="text-align: justify;">Alzheimer, a chronic neurodegenerative disease, usually starts slowly and worsens gradually. It causes 60% to 70% of dementia cases. Difficulty in remembering recent events (short-term memory loss) is the most prominent early symptom. As the disease progresses, patients may have problems such as impaired language, disorientation (including easily getting lost), mood swings, loss of motivation, not managing self-care, and behavioral issues. The potential damaging effect of air pollution on the central nervous system is also investigated and there&#39;s mounting evidence of a link between air pollution exposure and neurodegenerative pathologies, especially Alzheimer&#39;s disease. Air pollution is thought to increase the risk of neurological diseases by developing neuro-inflammation, oxidative stress, glial activation and cerebrovascular damage. In animal models, contaminated particles can activate microglial cells and increase the secretion of IL-6, IL-1b, and TNF-a, leading to neuro-inflammation. Also, exposure to complex mixtures of air pollutants produces inflammation in the upper and lower respiratory tract and causes systemic inflammation; As a result, neuro-inflammation and neuropathology then lead to Alzheimer. In polluted regions, we expect a higher level of systemic inflammation, prefrontal white matter hyper-intensities, and hallmarks of Alzheimer.</div> Air Pollution, Neuro Inflammation, Neuropathology, Alzheimer`S Disease 187 187 http://shefayekhatam.ir/browse.php?a_code=A-10-24-1207&slc_lang=en&sid=1 Sara Abbasi Sara Abbasi maah.titi.1997297@gmail.com 100319475328460016218 100319475328460016218 Yes Mashhad University of Medical Sciences, Mashhad, Iran Mashhad University of Medical Sciences, Mashhad, Iran Motahareh Mirdoosti Seyedeh Motahareh Mirdoosti 100319475328460016219 100319475328460016219 No Mashhad University of Medical Sciences, Mashhad, Iran Mashhad University of Medical Sciences, Mashhad, Iran Hojjat Shadman Zahroodi Hojjat Shadman Zahroodi 100319475328460016220 100319475328460016220 No Mashhad University of Medical Sciences, Mashhad, Iran Mashhad University of Medical Sciences, Mashhad, Iran Mohammad Mirzaei Mohammad Mirzaei 100319475328460016221 100319475328460016221 No Mashhad University of Medical Sciences, Mashhad, Iran Mashhad University of Medical Sciences, Mashhad, Iran