en P64: Increased Proportion of Tc17 and Th17 Cells and their Significant Reduction after Thymectomy may be Related to Disease Progression in Myastenia Gravis تحقیقات پایه در علوم اعصاب Basic research in Neuroscience پژوهشي Research --- Open Access, CC-BY-NC &nbsp; <table border="0" cellpadding="5" cellspacing="2" dir="rtl" id="table_article" style="text-transform: none; text-indent: 0px; letter-spacing: normal; font-family: Tahoma; word-spacing: 0px; orphans: 2; widows: 2; break-inside: avoid !important; background-color: rgb(251, 250, 249); -webkit-text-stroke-width: 0px; text-decoration-style: initial; text-decoration-color: initial;" width="100%"> <tbody style="text-align: justify; line-height: 2.2; font-size: 12px; margin-top: 0px; margin-bottom: 0px; break-inside: avoid !important;"> <tr style="break-inside: avoid !important;"> <td class="abstractmed" colspan="2" style="text-align: justify; break-inside: avoid !important;"> <p style="text-align: center; font-size: 12px; margin-top: 0px; margin-bottom: 0px;"><span style="text-align: center; color: rgb(0, 0, 0); font-family: Tahoma; font-size: 12px; background-color: rgb(251, 250, 249);">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> </td> </tr> <tr style="break-inside: avoid !important;"> </tr> </tbody> </table> <div style="text-align: justify;">Myasthenia gravis (MG) is an autoimmune disease mediated by auto-antibodies against the neuromuscular junction. The thymus has an important role in the pathogenesis of MG because most of the patients have thymic pathology and thymectomy (TE) can reduce the severity of the disease. In the present study, the frequency of Th17 and Tc17 cells were studied in MG patients (pre and 6 months post-TE) and healthy controls. We recruited 12 MG patients from the Shariati Hospital, Tehran, Iran, and the Alzahra Hospital, Isfahan, Iran, and 12 age- and sex-matched HC from the outpatient service of our institution (Department of Immunology, Isfahan Medical School, Isfahan, Iran) from April 2016 to May 2017. The frequency of Tc17 cells in pre-TE patients was significantly higher than HC (p <0.05) and after thymectomy Tc17 cells significantly decreased compared to the pre-TE (p <0.05). The frequency of Th17 cells in pre-TE patients was significantly higher than HC (p <0.05) and after thymectomy Th17 cells significantly decreased compared to the pre-TE (p <0.05). Our findings indicated a possible role of Tc17 and Th17 in MG pathogenesis.<br> &nbsp;</div> Myasthenia Gravis, Thymectomy, Th17, Tc17 95 95 http://shefayekhatam.ir/browse.php?a_code=A-10-24-1223&slc_lang=en&sid=1 Nasim Nehzat Nasim Nehzat n.nehzat96@gmail.com 100319475328460015715 100319475328460015715 Yes Isfahan Neurosciences Research Center, Alzahra Hospital, Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran Isfahan Neurosciences Research Center, Alzahra Hospital, Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran Nafiseh Esmaeil Nafiseh Esmaeil 100319475328460015716 100319475328460015716 No Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Vahid Shaygannejad Vahid Shaygannejad 100319475328460015717 100319475328460015717 No Isfahan Neurosciences Research Center, Alzahra Hospital, Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran Isfahan Neurosciences Research Center, Alzahra Hospital, Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran Shahriar Nafissi Shahriar Nafissi 100319475328460015718 100319475328460015718 No Iranian Center for Neurological Research, Department of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Iranian Center for Neurological Research, Department of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Omid Mirmossayeb Omid Mirmossayeb 100319475328460015719 100319475328460015719 No a. Isfahan Neurosciences Research Center, Alzahra Hospital, Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran b. Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran a. Isfahan Neurosciences Research Center, Alzahra Hospital, Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran b. Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran