The Neuroscience Journal of Shefaye Khatam
مجله علوم اعصاب شفای خاتم
Shefaye Khatam
Medical Sciences
http://shefayekhatam.ir
1
admin
2322-1887
2345-4814
10.61186/shefa
fa
jalali
1397
1
1
gregorian
2018
4
1
6
2
online
1
fulltext
en
P64: Increased Proportion of Tc17 and Th17 Cells and their Significant Reduction after Thymectomy may be Related to Disease Progression in Myastenia Gravis
P64: Increased Proportion of Tc17 and Th17 Cells and their Significant Reduction after Thymectomy may be Related to Disease Progression in Myastenia Gravis
تحقیقات پایه در علوم اعصاب
Basic research in Neuroscience
پژوهشي
Research --- Open Access, CC-BY-NC
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<div style="text-align: justify;">Myasthenia gravis (MG) is an autoimmune disease mediated by auto-antibodies against the neuromuscular junction. The thymus has an important role in the pathogenesis of MG because most of the patients have thymic pathology and thymectomy (TE) can reduce the severity of the disease. In the present study, the frequency of Th17 and Tc17 cells were studied in MG patients (pre and 6 months post-TE) and healthy controls. We recruited 12 MG patients from the Shariati Hospital, Tehran, Iran, and the Alzahra Hospital, Isfahan, Iran, and 12 age- and sex-matched HC from the outpatient service of our institution (Department of Immunology, Isfahan Medical School, Isfahan, Iran) from April 2016 to May 2017. The frequency of Tc17 cells in pre-TE patients was significantly higher than HC (p <0.05) and after thymectomy Tc17 cells significantly decreased compared to the pre-TE (p <0.05). The frequency of Th17 cells in pre-TE patients was significantly higher than HC (p <0.05) and after thymectomy Th17 cells significantly decreased compared to the pre-TE (p <0.05). Our findings indicated a possible role of Tc17 and Th17 in MG pathogenesis.<br>
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Myasthenia Gravis, Thymectomy, Th17, Tc17
95
95
http://shefayekhatam.ir/browse.php?a_code=A-10-24-1223&slc_lang=en&sid=1
Nasim
Nehzat
Nasim
Nehzat
n.nehzat96@gmail.com
100319475328460015715
100319475328460015715
Yes
Isfahan Neurosciences Research Center, Alzahra Hospital, Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran
Isfahan Neurosciences Research Center, Alzahra Hospital, Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran
Nafiseh
Esmaeil
Nafiseh
Esmaeil
100319475328460015716
100319475328460015716
No
Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Vahid
Shaygannejad
Vahid
Shaygannejad
100319475328460015717
100319475328460015717
No
Isfahan Neurosciences Research Center, Alzahra Hospital, Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran
Isfahan Neurosciences Research Center, Alzahra Hospital, Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran
Shahriar
Nafissi
Shahriar
Nafissi
100319475328460015718
100319475328460015718
No
Iranian Center for Neurological Research, Department of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
Iranian Center for Neurological Research, Department of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
Omid
Mirmossayeb
Omid
Mirmossayeb
100319475328460015719
100319475328460015719
No
a. Isfahan Neurosciences Research Center, Alzahra Hospital, Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran b. Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
a. Isfahan Neurosciences Research Center, Alzahra Hospital, Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran b. Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran