en P166: The Role of Interlukin-6 of Immune Cells in Neuronal Dysfunctions in the Autism Disease تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <div style="text-align: center;"><span style="background:#FBFAF9;"><span style="color:black;"><span style="font-family:tahoma,sans-serif;"><span style="font-size:9.0pt;">لطفاً به چکیده انگلیسی مراجعه شود</span></span></span></span><span dir="LTR" style="background:#FBFAF9;"><span style="color:black;"><span style="font-family:tahoma,sans-serif;"><span style="font-size:9.0pt;">.</span></span></span></span></div> <div style="text-align: justify;">About thirty years ago, the interlukin-6 (IL-6) which is the proinflammatory cytokine, was detected as the differentiation factor of B cell. IL-6 is able to induce maturation in B cells and as a result, B cells achieve the ability to produce antibodies. In addition to immune responses, the role of IL-6 has been known in neurogenesis (neurons and glial cells). The studies have showed that the abnormal immune responses are associated to the autism. In the autism disease, the levels of cytokines increase in blood, brain and cerebrospinal fluid (CSF). Conclusion: Increased levels of IL-6 in the brain of mouse are related to the autism properties such as abnormal cognitive abilities, loss of learning, anxiety, abnormal habits and reduction of social behaviors. Furthermore, Increased levels of IL-6 are associated to preventing of the transmission of inhibiting/inducing synaptic secretions. Also, IL-6 results in abnormal changing in the shape, length and distribution pattern of dendritic cells and can be neurotoxic. Findings show that the increase of IL-6 in the brain can relatively mediate the autism-like behaviors which are created by unbalancing the neuron circuits and dysfunctions of synaptic formations. High expression of IL-6 in several major brain diseases and animal models shows that it can play an important role in neuropathology and that is why IL-6 is the target for strategic treatment.</div> Autism, Interlukin, Nuerogenesis 197 197 http://shefayekhatam.ir/browse.php?a_code=A-10-24-1230&slc_lang=en&sid=1 Sedighe Abdollahzadeh Sedighe Abdollahzadeh 100319475328460016250 100319475328460016250 No Department of Basic Science, Molecular Genetics Faculty, Zahedan University, Zahedan, Iran Department of Basic Science, Molecular Genetics Faculty, Zahedan University, Zahedan, Iran Milad Ashrafizadeh Milad Ashrafizadeh dvm.milad73@yahoo.com 100319475328460016251 100319475328460016251 Yes Department of Basic Science, Veterinary Medicine Faculty, Tabriz University, Tabriz, Iran Department of Basic Science, Veterinary Medicine Faculty, Tabriz University, Tabriz, Iran Vahab Asemani Vahab Asemani 100319475328460016252 100319475328460016252 No Department of Basic Science, Veterinary Medicine Faculty, Tabriz University, Tabriz, Iran Department of Basic Science, Veterinary Medicine Faculty, Tabriz University, Tabriz, Iran