en P168: Delayed Imatinib Treatment for Spinal Cord Damage; Role of Serum Biomarkers and Recovery تحقیقات پایه در علوم اعصاب Basic research in Neuroscience مروری Review --- Open Access, CC-BY-NC <div style="text-align: center;"><span style="background:#FBFAF9;"><span style="color:black;"><span style="font-family:tahoma,sans-serif;"><span style="font-size:9.0pt;">لطفاً به چکیده انگلیسی مراجعه شود</span></span></span></span><span dir="LTR" style="background:#FBFAF9;"><span style="color:black;"><span style="font-family:tahoma,sans-serif;"><span style="font-size:9.0pt;">.</span></span></span></span></div> <div style="text-align: justify;">With no routine accessible medicine intervention for spinal cord damage, there is a demand for more remedial candidates. However, for Imatinib to have translational price, it requires to have encouraged obliging effects with delayed start of treatment, as well. Serum levels of 3 chemokines/ cytokines, MIP-3&alpha;, MCP-1, and GRO/ KC (IL-8), to raise over time with Imatinib treatment and to be obviously higher in damaged Imatinib treated animals than in manages pending the early treatment period. Lymphoid organs, first the spleen, were tested to supply information on systemic effects of Imatinib with consider to inflam- matory responses and lymphoid organs as the source of monocyte/ macrophage infiltration into the damage site of the spinal cord. Serum samples at one, three and seven days after damage were tested for INF-1&beta;, MIP-3&alpha;, MCP-1, IL-2, IL-4, IL-5, IL-6, IL-10, IL-13, GRO/ KC and TNF. Three cytokines/chemokines, MIP-3a, MCP-1 and GRO/ KC demonstrated definite potential as biomarkers in serum. Serum levels of MIP-3&alpha; and MCP-1 were raised one day after damage or sham surgery. GRO/KC concentrations were instead higher in the sham group compared to the contusion-damaged groups without or with Imatinib treatment, making this chemokine a potential serum biomarker for CNS damage. At one day after surgery, there was however no strong effect of Imatinib treatment of animals with spinal cord damage among the tested chemokines. Serum concentrations of MCP-1 and MIP-3a remained elevated in the damaged and sham damaged group throughout the seven days in comparison to concentrations in uninjured managements.</div> Spinal Cord Damage, Serum Biomarkers, Chemokines, Treatment 199 199 http://shefayekhatam.ir/browse.php?a_code=A-10-24-1235&slc_lang=en&sid=1 Moosa Javdani Moosa Javdani 100319475328460016257 100319475328460016257 No Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran Roya Ghorbani Ghahfarokhi Roya Ghorbani Ghahfarokhi 100319475328460016258 100319475328460016258 No Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran Maryam Nafar Sefid Dashti Maryam Nafar Sefid Dashti maryamnafar19@yahoo.com 100319475328460016259 100319475328460016259 Yes Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran Abolfazl Barzegar Bafrouei Abolfazl Barzegar Bafrouei 100319475328460016260 100319475328460016260 No Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran Marzieh Sadeghi Sefid Dashti Marzieh Sadeghi Sefid Dashti 100319475328460016261 100319475328460016261 No Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran