en P73: Nano-Phytosome of Curcumin Improve Behavioral Impairment on Carrageenan-Induced Acute Inflammation Model in Mice تحقیقات پایه در علوم اعصاب Basic research in Neuroscience پژوهشي Research --- Open Access, CC-BY-NC &nbsp; <table border="0" cellpadding="5" cellspacing="2" dir="rtl" id="table_article" style="text-transform: none; text-indent: 0px; letter-spacing: normal; font-family: Tahoma; word-spacing: 0px; orphans: 2; widows: 2; break-inside: avoid !important; background-color: rgb(251, 250, 249); -webkit-text-stroke-width: 0px; text-decoration-style: initial; text-decoration-color: initial;" width="100%"> <tbody style="text-align: justify; line-height: 2.2; font-size: 12px; margin-top: 0px; margin-bottom: 0px; break-inside: avoid !important;"> <tr style="break-inside: avoid !important;"> <td class="abstractmed" colspan="2" style="text-align: justify; break-inside: avoid !important;"> <p style="text-align: center; font-size: 12px; margin-top: 0px; margin-bottom: 0px;"><span style="text-align: center; color: rgb(0, 0, 0); font-family: Tahoma; font-size: 12px; background-color: rgb(251, 250, 249);">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> </td> </tr> <tr style="break-inside: avoid !important;"> </tr> </tbody> </table> <div style="text-align: justify;">Inflammatory disorders alone or as a consequence of neurological disease affecting patients in life. Experimental models of inflammation are use to evaluate the production of inflammatory mediators at site of inflammation. Curcumin is one of the flavonoids possesses potent anti-inflammatory activity. However, because of low water solubility curcumin, its clinical application has been limited. The present study attempts to assessment the effects of curcumin and nano-phytosome of curcumin on improve of behavioral impairment and reduce inflammation cytokines in carrageenan-induced inflammation model. Animals have received oral administration of curcumin or nano-phytosom of curcumin at dose of 15 mg/kg for 7 days before injection of carrageenan. Acute inflammation was induced by injection of carrageenan (1%,) into the subplantar region of left paw in mice. Tail pinch test and hotplate test (for evaluated the threshold of neuroinflammation pain) were performed on &frac12; h before injection and&nbsp; &frac12; h, 2 h, 24 h after injection of carrageenan. The results of behavioral testes showed enhance of&nbsp; antinociceptive effects in the animals recieved curcumin(p&le;0.01) and nano-phytosome of curcumin (p&le;0.001) compaired to other groups. These results suggested that curcumin and its nano-phytosome improvement behavioral impairment and reduce inflammation cytokines following local injection of carrageenan.<br> &nbsp;</div> Carrageenan, Inflammation, Nano-Phytosome of Curcumin, Inflammation Cytokines 104 104 http://shefayekhatam.ir/browse.php?a_code=A-10-24-1239&slc_lang=en&sid=1 Saeideh Baradaran Saeideh Baradaran baradaran.phi95@gmail 100319475328460015755 100319475328460015755 Yes Department of Biology, Faculty of Basic Sciences, University of Mazandaran, Mazandaran, Iran Department of Biology, Faculty of Basic Sciences, University of Mazandaran, Mazandaran, Iran Akbar Hajizadeh Moghaddam Akbar Hajizadeh Moghaddam 100319475328460015756 100319475328460015756 No Department of Biology, Faculty of Basic Sciences, University of Mazandaran, Mazandaran, Iran Department of Biology, Faculty of Basic Sciences, University of Mazandaran, Mazandaran, Iran Sedigheh Khanjani Jelodar Sedigheh Khanjani Jelodar 100319475328460015757 100319475328460015757 No Faculty of Basic Sciences, Shahid Beheshti University, Tehran, Iran Faculty of Basic Sciences, Shahid Beheshti University, Tehran, Iran