en P75: Expression of GDNF Genes in the Cerebellum of Rat Neonate Born to Mother with Diabetes تحقیقات پایه در علوم اعصاب Basic research in Neuroscience پژوهشي Research --- Open Access, CC-BY-NC &nbsp; <table border="0" cellpadding="5" cellspacing="2" dir="rtl" id="table_article" style="text-transform: none; text-indent: 0px; letter-spacing: normal; font-family: Tahoma; word-spacing: 0px; orphans: 2; widows: 2; break-inside: avoid !important; background-color: rgb(251, 250, 249); -webkit-text-stroke-width: 0px; text-decoration-style: initial; text-decoration-color: initial;" width="100%"> <tbody style="text-align: justify; line-height: 2.2; font-size: 12px; margin-top: 0px; margin-bottom: 0px; break-inside: avoid !important;"> <tr style="break-inside: avoid !important;"> <td class="abstractmed" colspan="2" style="text-align: justify; break-inside: avoid !important;"> <p style="text-align: center; font-size: 12px; margin-top: 0px; margin-bottom: 0px;"><span style="text-align: center; color: rgb(0, 0, 0); font-family: Tahoma; font-size: 12px; background-color: rgb(251, 250, 249);">لطفاً به چکیده انگلیسی مراجعه شود.</span></p> </td> </tr> <tr style="break-inside: avoid !important;"> </tr> </tbody> </table> <div style="text-align: justify;">Diabetes Mellitus as a common metabolic disorder in women of reproductive age is rising throughout the globe. Diabetes in pregnancy has various adverse outcomes on different organs development including the central nervous system (CNS) and it can cause learning deficits, behavioral problems and motor dysfunctions in the offspring. The cerebellum is a part of brain that coordinates voluntary movements and controls balance and also participate for motor learning, and language processing. Neurodevelopmental assessment of the child born to diabetic mothers has displayed a short and long-term neurocognitive and neurobehavioral abnormalities in the offspring. Even though neuronal death has also known the main leading cause of diabetic CNS and peripheral neuropathies, the exact mechanism of neuronal death in diabetes type I mellitus has not been completely understood yet. Neurotrophic factor family (NTFs) consists of: nerve growth factor (NGF) family, glial cell line-derived neurotrophic factor family ligands (GDNF) and some cytokines. Several processes in neuronal cells such as survival, migration, neurite outgrowth, formation of synapses and neuronal plasticity are controlled by NTFs. In the majority of experimental studies the important role of GDNF and its receptor components (GFR&alpha;1 and Ret) in the survival of different populations of neurons in the central and peripheral nervous systems have been proved. Beside the expression of GDNF in developing Purkinje cell and granule cell layers in many researches has shown. In spite of the fact that subsequent studies demonstrated molecular layer interneuron (MLIs) are essential for normal cerebellar function and motor learning, signals controlling survival and mechanisms migration of Purkinje cells (PCs) from the ventricular zone to form the PC plate during embryonic development of the cerebellum are incompletely unknown. In previous studies reported that the neurotrophic receptor GFRa1 is transiently expressed in developing PCs and loss of GFRa1 delays PC migration. Regarding above mentioned facts, since cerebellum is one of the important parts in the brain for memory/learning processing; on the other hand expression GDNF and GFR&alpha;-1 is essential for the development and PCs migration, this study aimed to investigate mRNA expression and distribution pattern of GDNF in different layers of cerebellum in early postnatal development in diabetics&#39; rat off springs.<br> &nbsp;</div> GDNF, Cerebellum, Purkinje Cells 106 106 http://shefayekhatam.ir/browse.php?a_code=A-10-24-1245&slc_lang=en&sid=1 Mina Mohasel Roodi Mina Mohasel Roodi mina.mohasel@bums.ac.ir 100319475328460015764 100319475328460015764 Yes Department of Anatomical Sciences, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran Department of Anatomical Sciences, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran Faezah Idoon Faezah Idoon 100319475328460015765 100319475328460015765 No Department of Anatomical Sciences, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran Department of Anatomical Sciences, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran Hadi Asghari Hadi Asghari 100319475328460015766 100319475328460015766 No Institute of Microstructure Technology (ITM), Karlsruhe Institute of Technology, Karlsruhe, Germany Institute of Microstructure Technology (ITM), Karlsruhe Institute of Technology, Karlsruhe, Germany Ghasem Ivar Ghasem Ivar 100319475328460015767 100319475328460015767 No Department of Anatomical Sciences, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran Department of Anatomical Sciences, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran Zohreh Sedghi Zohreh Sedghi 100319475328460015768 100319475328460015768 No School of Medicine, Birjand University of Medical Sciences, Birjand, Iran School of Medicine, Birjand University of Medical Sciences, Birjand, Iran Javad Hami Javad Hami 100319475328460015769 100319475328460015769 No a. Department of Anatomical Sciences, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran b. Institute of Microstructure Technology (ITM), Karlsruhe Institute of Technology, Karlsruhe, Germany a. Department of Anatomical Sciences, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran b. Institute of Microstructure Technology (ITM), Karlsruhe Institute of Technology, Karlsruhe, Germany Mohamad Mahdi Hasanzadeh Taheri Mohamad Mahdi Hasanzadeh Taheri 100319475328460015770 100319475328460015770 No Department of Anatomical Sciences, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran Department of Anatomical Sciences, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran Akram Sadeghi Akram Sadeghi 100319475328460015771 100319475328460015771 No a. Department of Anatomical Sciences, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran b. Cellular and Molecular Research Center, Birjand University of Medical Science, Birjand, Iran a. Department of Anatomical Sciences, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran b. Cellular and Molecular Research Center, Birjand University of Medical Science, Birjand, Iran