fa Berberine Attenuates Convulsing Behavior in 4-aminopyridine Treated Rats نورولوژی Neurology خلاصه مقاله همایش Conference Paper Abstract <div dir="ltr" style="text-align: justify;"><strong>Introduction:</strong> 4-Aminopyridine (4-AP), a K+ channel blocker, causes seizures by stimulating the release of glutamate from nerve terminals. The natural isoquinoline alkaloid berberine has neuroprotective properties. The present study aimed to investigate the effect of berberine on seizure onset produced by 4-AP in rats. <strong>Materials and Methods:</strong> The rats were given berberine (50, 100, and 200 mg/kg, IP) 40 min before administration of 4-AP (15 mg/kg, IP), and the onset of seizure was recorded. Additionally, diazepam (DZP, 15 mg/kg, IP) was given to a group of rats 20 minutes before 4-AP was administered. <strong>Results: </strong>The beginning of the seizure was markedly postponed by berberine following the 4-AP injection. <strong>Conclusion: </strong>Our findings imply that berberine may be able to stop seizures brought on by 4-AP. This research highlights the therapeutic potential of berberine to treat neurological diseases.<br> &nbsp;</div> <strong>Introduction:</strong> 4-Aminopyridine (4-AP), a K+ channel blocker, causes seizures by stimulating the release of glutamate from nerve terminals. The natural isoquinoline alkaloid berberine has neuroprotective properties. The present study aimed to investigate the effect of berberine on seizure onset produced by 4-AP in rats. <strong>Materials and Methods:</strong> The rats were given berberine (50, 100, and 200 mg/kg, IP) 40 min before administration of 4-AP (15 mg/kg, IP), and the onset of seizure was recorded. Additionally, diazepam (DZP, 15 mg/kg, IP) was given to a group of rats 20 minutes before 4-AP was administered. <strong>Results: </strong>The beginning of the seizure was markedly postponed by berberine following the 4-AP injection. <strong>Conclusion: </strong>Our findings imply that berberine may be able to stop seizures brought on by 4-AP. This research highlights the therapeutic potential of berberine to treat neurological diseases.<br> &nbsp; Seizures, Plants, Medicinal, Epilepsy Seizures, Plants, Medicinal, Epilepsy 4 4 http://shefayekhatam.ir/browse.php?a_code=A-11-24-1440&slc_lang=fa&sid=1 Fatemeh Forouzanfar Fatemeh Forouzanfar forouzanfarf@mums.ac.ir 100319475328460027325 100319475328460027325 Yes Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Hamid Reza Sadeghnia Hamid Reza Sadeghnia 100319475328460027326 100319475328460027326 No Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran Ali Reza Taji Taji Ali Reza 100319475328460027327 100319475328460027327 No Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran Hossein Hosseinzadeh Hossein Hosseinzadeh 100319475328460027328 100319475328460027328 No Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran