The Neuroscience Journal of Shefaye Khatam
مجله علوم اعصاب شفای خاتم
Shefaye Khatam
Medical Sciences
http://shefayekhatam.ir
1
admin
2322-1887
2345-4814
10.61186/shefa
fa
jalali
1393
9
1
gregorian
2014
12
1
2
4
online
1
fulltext
fa
P48: Self-Assembling Peptide Nanostructures as a Good Scaffold for Treatment of Spinal Cord Injury
P48: Self-Assembling Peptide Nanostructures as a Good Scaffold for Treatment of Spinal Cord Injury
تحقیقات پایه در علوم اعصاب
Basic research in Neuroscience
مروری
Review --- Open Access, CC-BY-NC
<p align="center">لطفاً به چکیده انگلیسی مراجعه شود. </p>
To date, various approaches have been used in attempt to treat spinal cord injury (SCI) but there is no definite treatment for repair of the damaged tissue. It is well known that SCI results in a loss of neural tissues and formation of cystic cavities that inhibit regeneration of axons. Tissue engineering, in which cells, signals and scaffolds are combined, is one of the most promising areas of research due to its potential to regenerate damaged or lost tissues. Peptide nanostructures formed through molecular self-assembly are increasingly important for material science and regenerative medicine. Peptide self-assembly allows the design and fabrication of supramolecular architectures at nanoscale. Self-assembling peptides (SAPs) have been developed under physiological conditions that can form 3 dimension structures of nanofibers. SAPs are amenable to injection due to their water solubility and exhibit dramatic morphology changes immediately after injection due to the addition of salts from the cerebro- spinal fluid. SAPs can reduce the glial reaction and support the host cells to migrate and fill the cavity. In addition, SAPs provide a 3 dimensional environment for axonal elongation and angiogenesis.With application of the biocompatible, non-toxic and biodegradable SAPs in SCI, we can help the injured tissue to repair and reconstruct.
SAPs, Scaffold, Spinal Cord Injury
98
98
http://shefayekhatam.ir/browse.php?a_code=A-10-24-445&slc_lang=fa&sid=1
Sajad
Sahab Negah
Sajad
Sahab Negah
10031947532846005865
10031947532846005865
No
a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran.
a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran.
Hadi
Aligholi
Hadi
Aligholi
10031947532846005866
10031947532846005866
No
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Mostafa
Modarres Mousavi
Mostafa
Modarres Mousavi
10031947532846005867
10031947532846005867
No
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Zabihollah
Khaksar
Zabihollah
Khaksar
10031947532846005868
10031947532846005868
No
Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran.
Histology and Embryology Group, Basic Science Department, Veterinary Medicine Faculty, Shiraz University, Shiraz, Iran.
Hadi
Kazemi
Hadi
Kazemi
10031947532846005869
10031947532846005869
No
a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Pediatric Department, Shahed University, Tehran, Iran.
a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Pediatric Department, Shahed University, Tehran, Iran.
Shahin
Mohammad Sadeghi
Shahin
Mohammad Sadeghi
drshmsadeghi@gmail.com
10031947532846005870
10031947532846005870
Yes
Department of Plastic and Reconstructive Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Plastic and Reconstructive Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.