The Neuroscience Journal of Shefaye Khatam
مجله علوم اعصاب شفای خاتم
Shefaye Khatam
Medical Sciences
http://shefayekhatam.ir
1
admin
2322-1887
2345-4814
10.61186/shefa
fa
jalali
1393
9
1
gregorian
2014
12
1
2
4
online
1
fulltext
fa
P78: Depakine Improve Axonal Growth In Vitro and In Vivo after Spinal Cord Injury
P78: Depakine Improve Axonal Growth In Vitro and In Vivo after Spinal Cord Injury
تحقیقات پایه در علوم اعصاب
Basic research in Neuroscience
پژوهشي
Research --- Open Access, CC-BY-NC
<p align="center">لطفاً به چکیده انگلیسی مراجعه شود. </p>
Central nervous system axons fail to regenerate after spinal cord injury (SCI), partially due to the accumulation of extracellular matrix molecules in the lesion and formation of the glial scar. Depakine, as known as histone deacetylase inhibitor, has neuroprotective effects. This study evaluated the histological changes (cavitation and axon regeneration) after SCI associated with (following administration of Depakine in rat model) Depakine treatment in a rat model. Sections were stained with silver impregnation to assess demyelination, and axonal regeneration. The injured spinal cord was then examined histologically, including quantification of cavitation. The cavity volume in the Depakine group was significantly reduced compared to the control (saline-injected) group (P<0.05). There were few axons could be noticed in the untreated group while the treated showed many axons in the regenerating spinal tissues. Depakine reduce inflammation after SCI, and is effective for histology and higher axonal regeneration.
Depakine, Axonal Regeneration, Neuroprotection, Demyelination
128
128
http://shefayekhatam.ir/browse.php?a_code=A-10-24-476&slc_lang=fa&sid=1
Marzieh
Darvishi
Marzieh
Darvishi
10031947532846005972
10031947532846005972
No
a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Department of Anatomy, Tarbiat Modares University, Tehran, Iran.
a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Department of Anatomy, Tarbiat Modares University, Tehran, Iran.
Taghi
Tiraihi
Taghi
Tiraihi
ttiraihi@yahoo.com
10031947532846005973
10031947532846005973
Yes
a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Department of Anatomy, Tarbiat Modares University, Tehran, Iran.
a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Department of Anatomy, Tarbiat Modares University, Tehran, Iran.
Taher
Taheri
Taher
Taheri
10031947532846005974
10031947532846005974
No
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.